非酒精性脂肪性肝病与代谢综合征相关性研究.pdf

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1、·1062·中华流行病学杂志2014年9YJ第35卷第9期ChinJEpidemiol，September2014，Vo1．35，No．9·『I床研究·非酒精性脂肪性肝病与代谢综合征相关性研究胡卫张苗旋谭金海【摘要】目的分析非酒精性脂肪性肝病(NAFLD)与MS的相关性。方法2010-2011年对武汉大学医院在校教职工体检包括询问病史、体格检查、生化检查、肝脏彩超检查。按NAFLD诊断标准将研究对象分为NAFLD组和非NAFLD组，对两组与MS及其相关因素进行比较分析。结果(1)NAFLD总患病率为20．7％，MS为13．3％，NAFLD组BMI、SBP、DBP、TG、FPG均较非NAFLD组

2、高，HDL—C水平低于非NAFLD组(P

3、ndmetabolicsyndromeHuWe．ZhangMiaoxuan．nJinhai．HospitalofWuhanUniversity。Wuhan430072。ChinaCorrespondingauthor：TanJinha，Email：2410746045@qq．corn【Abstract】0bjectiveToanalyzetherelationbetweennonalcoholicfattyliverdisease(NAFLD)andmetabolicsyndrome(MS)amongadultsfromtheFunctionalUniversitySociety(FUS)．M

4、ethodsThissurveywasconductedamongthestafofWuhanUniversitywhounderwentphysicalcheck．upsfrom2010to2Ol1attheAffiliatedHospitalofWuhanUniversity．Thepattieipantshadrecordsrelatedtomedicalhistory，clinica1examination，anthropometry，1aboratorytestsandroutineliverultrasonography．Accordingtothediagnosticcriter

5、iaofNAFLD．thecasesweredividedintotwogrOups—withNAFLDorwithout．MSanditsrelevantriskfactorsofthetwogroupswerecompared．Results1)TheprevalenceratesofnonalcoholicfattyliverdiseaseandMSwere20．7％．andl3-3％，respectively．PeoplewithnonalcoholicfattyliverdiseasehadhigherlevelsofBMI。SBP，DBP，TG。FPGand1owerlevelof

6、HDL—Cthanthosewhodidnothavetheproblem．2)TherisksofNAFLDgroupindevelopingMS。obesity．hypertensionanddyslipidemiawerehigherthanthenon—group(P<0．001)．3)TheNAFLDgrouphad1．66，4．22，8．72and25．62timeschancesofhaving1to4riskfactorsonMSthanthosewithoutNAFLD．ConclusionNAFLDwascloselyassociatedwithMSanditsreleva

7、ntriskfactors．【Keywords】Nonalcoholicfattyliverdisease；Metabolicsyndrome；Relativityanalysis非酒精性脂肪性肝病(NAFLD)和MS患病率目名教工体检资料中，剔除患自身免疫性肝炎和肝硬前呈现明显上升趋势，普遍的观点认为NAFLD是化、继发性高血压、血吸虫病史者，并排除有长期饮MS的一种肝脏表现。为分析NAFLD与