非酒精性脂肪肝与2型糖尿病肾损伤关系的研究.pdf

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1、·10·医药论坛杂志2014年1月第35卷第1期JMedicalForumVo1．35No．1January2014非酒精性脂肪肝与2型糖尿病肾损伤关系的研究商慧鲜，李华，杨再刚，李天艺郑州大学第一附属医院老年内分泌科，郑州450052摘要：目的探讨非酒精性脂肪肝(NAFLD)与2糖尿病肾损伤发生风险之间的关系。方法T2DM患者466例，分为T2DM伴NAFLD组(N组，n=266)及T2DM不伴NAFLD组(NN组，n：200)，测定24h尿微量白蛋白排泄率(UAER)，比较两组间肾脏损伤发生率。结果N组BMI

2、、DBP、FPG、FCP、FINS、HbA1c、HOMA—IR、TC、TG、ALT、UAER高于NN组(P<0．05)；N组的肾损伤发生率高于NN组(P<0．05)；Logistic回归分析显示，NAFLD是2糖尿病肾损伤的独立危险因素(P

3、ciationsbetweennonalcoholicfattyliverdiseaseandrenalinjuryinpatientswithtype2diabetesSHANGHui—xian，LIHua，YANGZai—gang，LITian—yiDepartmentofEndocrinologyingerontology，theFirstAfiliatedHospitalofZhengzhouUniversity，Zhengzhou450052，ChinaAbstract：ObjectiveToinves

4、tigatetheassociationsbetweennon—alcoholicfattyliverdisease(NAFLD)andrenalin·juryinacohortoftype2diabeticindividuals．MethodsFourhundredandsixty—sixpatientswereinvestigatedrespectively．Prevalencesofrenalinjuryinpatientswithtype2diabeteswereassessedin466type2dia

5、beticpatients，whoweredividedintotwogroupsbythepresenceofNAFLD．T2DMwithNAFLDgroup(Ngroup，n=266)andT2DMwithoutNAFLDgroup(NNgroup，n=200)．Theincidenceofrenaldatnageinpatientswithtype2diabeteswasassessedbytestingthe24hurinaryalbuminexcretionrate(UAER)．ResultsCompa

6、redwithdiabeticpatientswithoutNAFLD，thepa—tientswithNAFLDhadsignificantlyhigherBMI，DBP，FPG，FCP，FINS，HbA1c，HOMA—IR，TC，TG，ALT，UAER(P<0．05)．NgrouppatientshadremarkablyhigherrenalinjuryprevalencethantheircounterPartsNNgroup(P<0．05)．Inmultivariatelogisticregressio

7、nanalysis，NAFLDwasindependentlyassociatedwithprevalentofrenalinjuryinpatientswithtype2diabetes(P<0．05)．TheseassociationswereindependentofSBP，DBP，TC，TG，HDL—C．ConclusionTheincidencesofrenalinjuryinpatientswithtype2diabete~weresignificantlyhigherinthepatientswit

8、hNAFLDthanthosewithoutNAFLD．OurfindingssuggestthatNAFLDisindependentlyofseveralconfoundingfactors，withahigherprevalenceofrenalinjuryintype2diabeticindividuals．Keywords：Type2diabetesmellit