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1、ChineseJournalofNaturalChineseJournalofNaturalMedicines2009,7(5):0346−0350Medicinesdoi:10.3724/SP.J.1009.2009.00346TriterpeneGlycosidesfromSeaCucumberHolothurialeucospilota1,21*113HANHua,YIYang-Hua,LILing,LIUBao-Shu,PANMin-Xiang,41YANBing,WANGXiao-Hua1Researc
2、hCenterforMarineDrugs,SchoolofPharmacy,SecondMilitaryMedicalUniversity,Shanghai200433;2CollegeofAnimalSciences,ZhejiangUniversity,Hangzhou310029;3PLA306HospitalPharmacyDepartment,Beijing100101;4DepartmentofPharmaceuticals,NanjingGeneralHospitalofNanjingMilita
3、ryRegion,Nanjing210002,ChinaAvailableonline:20Sep2009[ABSTRACT]AIM:TofindnewbioactivetriterpeneglycosidesfromtheseacucumberHolothurialeucospilota.METHODS:Col-umnchromatographyonsilicagelandODSRP-C18andHPLCwereusedfortheisolationandpurificationoftriterpeneglyc
4、osides,andtheirstructureswereelucidatedonthebasisofspectraldataandchemicalevidence.RESULTS:SeventriterpeneglycosideswereisolatedfromtheseacucumberH.leucospilota,andidentifiedasleucospilotasideA(1),leucospilotasideB(2),leucospilotasideC(3),holothurinB(4),holot
5、hurinB2(5),echinosideB(6),andholothurinA(7).CONCLUSION:Compound2isanewtriterpeneglyco-side,andcompounds1,3,5and6havebeenisolatedfromthisseacucumberforthefirsttime.[KEYWORDS]Seacucumber;Holothurialeucospilota;Triterpeneglycosides.[CLCNumber]R284[Documentcode]A
6、[ArticleID]1672-3651(2009)05-0346-051IntroductioninvestigatedtheBuOHextractofH.leucospilota.ThreenewcompoundsandfourknowncompoundswereisolatedMorethan1100seacucumberspecies(Echinodermata)fromH.leucospilota.Here,wereporttheisolationandarewidelydistributedinthe
7、world.Thereare500speciesinstructuralelucidationofthetriterpeneglycosides.China,about40ofwhichareedible.H.leucospilota(fam-ilyHolothuriidea),distributedabundantlyintheSouthChina2Experimental[1]sea,hasbeenusedasatonicinChina.Triterpenegly-2.1GeneralExperimental
8、ProcedurescosidesarethepredominantsecondarymetabolitesoftheseaMeltingpointsweredeterminedonanXT5-XMTappa-cucumber,exhibitingwidespectraofbiologicalactivities,ratus.Opticalrotationsweremea
