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1、GLP-1受体激动剂对2型糖尿病患者的疗效观察童强王慧管凌志王小翠郑宏庭*（第三军医大学新桥医院内分泌科）【摘要】目的GLP-1受体激动剂艾塞那肽对2型糖尿病患者临床疗效的观察。方法选取住院的2型糖尿病患者78例，随机分为两组（对照组、治疗组），治疗组给予二甲双胍联合艾塞那肽治疗，对照组给予二甲双胍联合甘精胰岛素治疗，观察两组空腹血糖（FBG）、餐后2小时血糖（PG2h）、糖化血红蛋白（HbA1c）、空腹C肽、餐后2小时C肽、体重指数（BMI)等相关指标。结果16周后两组受试对象的FBG、PG2h、HbA1c均
2、较入组前有所降低（P<0.05），但两组之间无明显统计学差异（P>0.05）；两组受试对象BMI均较治疗前有所下降，但治疗组降低更明显（P<0.05）。且治疗组空腹C肽及餐后2小时C肽水平均较治疗前有所增高（P<0.05），但对照组C肽治疗前后无明显变化（P>0.05）。结论艾塞那肽能够较好的降低2型糖尿病患者的血糖及糖化血红蛋白，在一定程度上能够改善2型糖尿病患者的胰岛β细胞功能。【关键词】GLP-1受体激动剂；艾塞那肽；2型糖尿病TheObservationontheEfficiencyofGLP-1Rec
3、eptorAgonistinPatientswithType2DiabetesQiangTong,HuiWang,LingzhiGuan,XiaocuiWang,HongtingZheng*(DepartmentofEndocrinology,XinqiaoHospital,ThirdMilitaryMedicalUniversity)[Abstract]ObjectiveTheobservationontheclinicalefficacyofexenatidewhichistheGLP-1ReceptorA
4、gonistinthetreatmentoftype2diabetes．Methods78hospitalizedpatientswithtype2diabetesweredividedintotwogroupsrandomly(thecontrolgroup,thetreatmentgroup).Thepatientsinthetreatmentgroupwerereceivedmetformincombinedwithexenatide,whereasthepatientsinthecontrolgroup
5、weregivenmetformincombinedwithGansulin,buttheirbloodglucosewerenotwellcontrolled.ThechangesofFBG，PG2h,HbA1c，fastingC-peptide,2hourspostprandialC-peptide,andBMIwerecomparedbeforeandaftertreatmentbetweentwogroups．ResultsAt16weeksafterthetreatment，FBG,PG2handHb
6、A1cweresignificantlydecreasedintwogroups(P<0.05)，buttherewasnostatisticaldifferencebetweenthetwogroups(P>0.05).TheBMIofallthepatientshaddecreased,andthisdecreasewasmoresignificantlyinthetreatmentgroupthaninthecontrolgroup(P<0.05).Furthermore,levelsoffastingC
7、-peptideand2hourspostprandialC-peptidewereincreasedinthetreatmentgroupafterthetreatment(P<0.05),butinthecontrolgrouptherewasnodifferencebeforeandafterthetreatment(P>0.05).ConclusionExenatidecaneffectivelydecreasethebloodglucoseandHbA1c.Nevertheless,exenatide
8、isbeneficialfortherecoveryofβ-cellfunctionsinT2DMtosomeextent.Keywords:GLP-1receptor;exenatide;type2diabetes胰高血糖素样肽-1（glucagon-likepeptide-1，GLP-1）受体激动剂是一种新型的降糖药物，能够通过刺激血糖依赖的胰岛素分泌、抑制食欲、减缓胃排空等来发挥
