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1、1、IGFBP-3与骨密度及骨代谢指标的关系?376?[文章编号]1000—4718(2007)o2—0376一o3中国病理生理杂志ChineseJournalofPathophysiology2007,23(2:3_3绝经后妇女骨质疏松患者血清IGF一1,IGFBP一3与骨密度及骨代谢指标的关系木吴文,智喜梅,李东风,林凯,杨艳红(广东省人民医院骨质疏松防治中心,广东广州510080)[摘要]目的:探讨胰岛素样生长因子一1(IGF一1)和胰岛素样生长因子结合蛋白一3(IGFBP一3)与绝经后妇女骨密度及骨代谢指标之
2、间的关系.方法:通过检测9o例绝经后妇女骨质疏松患者及70例绝经后骨量正常的健康对照组血清IGF一1,IGFBP一3,骨钙素(BGP),I型胶原异构c端肽(B—CTX),雌激素(E),降钙素(cT),甲状旁腺激素(Prn),钙(Ca),磷(P)等指标,然后同用双能x线骨密度仪检测的两组研究对象的腰椎(L2一L4)侧位,左股骨颈骨密度进行比较.结果:绝经后骨质疏松组妇女腰椎,股骨颈骨密度显着低于对照组(均P<0.01);血清IGF一1,IGFBP一3,E2,CT,BGP水平均低于对照组(均P<0.01);血
3、清B—CTX,PI'H均高于对照组(均P<0.O1),血清Ca,P两组之间无差异(均P>0.05).骨质疏松组和对照组腰椎侧位,左股骨颈BMD均与IGF一1,IGFBP一3,E,BGP,CT水平呈正相关,与B—CTX,PI'H水平呈负相关,而与血钙,血磷无明显关系.结论:IGF一1,IGFBP一3,E,BGP,CT,p—CTX,PTH血清水平与腰椎,左股骨质具有明显的相关性,通过检测上述指标可考虑作为筛查绝经后妇女是否容易患有骨质疏松症的一项有价值的生化参考指标.[关键词]绝经后骨质疏松;胰岛素生长因子;
4、骨密度[中图分类号】11363[文献标识码]ATherelationshipbetweenserumIGF一1,IGFBP一3levels,bonemineraldensityandbonemetabolicmarkersinpostmenopausalpatientswithoste-oporoslsWUWen,ZHIXi—mei,LIDong—feng,LINKai,YANGYan—hong(ResearchCenterofOsteoporosis,GuangdongProvincialPeople'sHospi
5、tal,Guangzhou510080,China.E—mad:WU-wen1964@163.corn)[ABSTRACT]AIM:Tostudytherelationshipbetweenseruminsulin—likegrowthfactor一1(IGF一1),insulin—likegrowthfactorbindingprotein一3(IGFBP一3)levels,bonemineraldensity(BMD)andbonemetabolicm&l'kel~inpoatmenopausalwome
6、n.METHODS:SerumIGF一1,IGFBP一3,osteocalcin(BGP),isomericC—telopeptideoftypeIcollagen(B—CTX),estradiol(E2),calcitonin(CT),parathormone(PTH),calcium(Ca),andphosphorus(P)weremeasuredin90postmenopausalosteoporosispatientsand70healthypostmenopausalwomen.BMDoflumbarver
7、tebraandleftfemoralneckweredeterminedbydualenergyX—rayabsorptiometry.RESULTS:BMDoflumbarvertebraandleftfem—oralneckdecreasedsignificantly(P<0.01),serumIGF—l,IGFBP一3,E2,CTandBGPdecreasedsignificantly(P<0.01),serumB—CTXandPTHincreasedsignificantlyinpostmeno
8、pausalosteoporosisgroup(P<0.O1).TherewerenosignificantlydifferencesinserumCa,Pbetweentwogroups(P>0.05).BMDoflumbarvertebraandleftfemoralneckwerepositivelycorrelatedwit
