欢迎来到天天文库
浏览记录
ID:52449660
大小:291.26 KB
页数:5页
时间:2020-03-27
《STM3基因多态性与抗结核药物性肝损伤的相关性分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华疾病控制杂志2014年7月第18卷第7期·585·论著GSTA1/GSTM3基因多态性与抗结核药物性肝损伤的相关性分析1211111高丽,李世明,史哲,贺蕾,张中瑞,宋磊,冯福民【摘要】目的探讨GSTA1、GSTM3基因多态性与汉族人群抗结核药物性肝损伤的关系。方法采用病例对照研究设计,随机选取抗结核治疗致肝损伤患者199例作为病例组,无肝损伤患者199例作为对照组。应用聚合酶链反应-限制性片段长度多态性检测研究对象GSTA1、GSTM3基因多态性,应用SPSS17.0统计软件进行分析。结果GSTA1基因C-69T位点的C、T等位基因在病例组的分布频率
2、分别82.4%、17.6%,在对照组的分布频率分2布为88.2%、11.8%,经检验得差异有统计学意义(=5.30,P=0.027);GSTM3在内含子6处3个碱基未缺失型(即野生型A)与缺失型(即突变型B)在病例组的分布频率分别为69.3%、30.7%;在对照组的分布频率为72.1%、227.9%,组间差异无统计学意义(=0.73,P=0.436)。GSTA1(T)/GSTM3(B)与GSTA1(C)/GSTM3(A)比较,2差异有统计学意义(=5.31,P=0.021)。GSTA1(T)/GSTM3(A)与GSTA1(C)/GSTM3(A)相比较
3、差异无统计学意义,但GSTA1(T)/GSTM3(A)发生ADIH风险升高(OR=1.572)。在调整了吸烟、饮酒影响因素后,GSTA1C-69T位点基因多态性与ADIH发生仍相关,其调整OR值为1.773。结论GSTA1基因多态性可能与抗结核药物性肝损伤发生相关;尚不能认为GSTM3基因多态性与抗结核药物性肝损伤发生存在相关性;GSTA1/GSTM3联合突变会导致抗结核药物性肝损伤的发生风险升高,GSTA1单一突变与均不突变相比,也会使ADIH发生的风险升高。【关键词】结核;抗结核药;肝疾病;多态性,限制性片段长度【中图分类号】R52;R181.3【文献
4、标识码】A【文章编号】1674-3679(2014)07-0585-05AnalysisoftherelationshipbetweenthegeneticpolymorphismsofglutathioneS-transferaseA1,M3(GSTA1,121GSTM3)andthesusceptibilitytoantituberculosisdrug-inducedhepatotoxicityGAOLi,LIShi-ming,SHIZhe,1111HELei,ZHANGZhong-rui,SONGLei,FENGFu-min.1.SchoolofP
5、ublicHealth,HebeiUnitedUniversity,KeyLaboratoryofOccupationalHealthandSafety,Tangshan063000,China;2.DepartmentofClinicalLaboratories,Tangs-hanTuberculosisHospital,Tangshan063000,China【Abstract】ObjectiveToexploretherelationshipbetweenGSTA1,GSTM3anddrug-inducedliverinjurybyanti-tube
6、rculosisdrugs.MethodsAcase-controlstudywasconducted.199ChineseHanpatientswithADIHwereselectedfromthepatientswhoreceivedtheanti-tuberculosistherapyastheADIHgroupand199personswhohadnothaveahepatic-injurywereselectedascontrols.Polymerasechainreaction-restrictionfragmentlengthpolymorp
7、hism(PCR-RFLP)usedtoidentifythegenotypesofGSTA1C-69Tgeneandintron6ofGSTM3.DatawereanalyzedbySPSS17.0software.ResultsTheGSTA1geneticpolymorphismsweredetectedin199casesand199controls.ThefrequencyofC/TofGSTA1were82.4%and17.6%respectivelyincasesand88.2%and11.8%incontrols.Thefrequencyo
8、fA/Binintron6ofGSTM3were69.3%and3
此文档下载收益归作者所有