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1、乌梢蛇血清对白眉蝮等3种蛇毒解毒作用初探2006年第18卷第3期蛇志JOURNALOFSNAKEVo1.18No.3,2006乌梢蛇血清对白眉蝮等3种蛇毒解毒作用初探胡恺,万新(1.华中师范大学第一附属中学,湖北武汉华,刘岱岳430223;2.武汉大学,湖北武汉430072)Preliminarystudyonthedetoxicatingactionofthreesnaketoxins(Agkistrodonhalysussuriensisetc.)bynonpoisoning178snake(Zaocysdhu
2、mnades)serumHUKai,WANXin—hua,LIUDai—yue(1.No.1MiddleSchoolofHuazhongNormalUniversity,Wuhan,Hubei,430223,China;2.UniversityofWuhan,Wuhan,Hubei,430072,China)Abstract:ObjectiveprobeintothedetoxificationonthevenomofBengalesecobra(NajanajaKaouthia)Agkistrodomblomho
3、ffiiussuriensis,andTrimeresusmangshanehsisiZhaobyZaozysdhumnadesserum.Methods18~22gNIHmalemouseswereinjectedtheven—omofBengalesecobra,Agkistrodomblomhoffiiussuriensis,Trimeresus,口g5^口P^55Zhaorespectively,ThentheZaocysdhumnadesserumwereinjectedatdifferentconcen
4、tra—tionfordetoxification.ResultsTheresultsshowedthat:(1)ItwasfoundthattheZao—cysdhumnadesserumhadagoodeffectontheBengalesecobrapoison.Andtheserumhadfluexcellenteffectafterthehybridliquidhadbeeninjected.The4ml/kgZaocysdhumnadesser—amhadagoodeffectonthehybridli
5、quidofthesnakepoison.ButtheeffectofZaocysdhum—hadesserumwouldbeweakenedgraduallywiththeextensionofthepartitiontime.(2)The4ml/kgZaocysdhumnadesserumhadagoodeffectontheAgkistrodomblomhoffiiUSSM—riensispoison.Theeffectwasexcellentafterthehybridliquidofthesnakepoi
6、sonhadbeeninjected.ButtheeffectoftheZaocysdhumnadesserumwouldbeweakenedgraduallywiththeextensionofthepartitiontime,andthelifedidntdiewhentheiniectingmeasurewaslml/kgand2ml/kg.(3)TheZaocysdhumnadesserumhadaneffectonthepoisonofTrim—eresus,口^口P^Zhao.ButtheTrimere
7、sus,口g^口P^isZhao'spoisonwasnotsen—sitivetothequantityoftheserumandpartitiontimeofinjecting.Thelifedidn'tdiewhentheinjectingmeasurewas2ml/kg.andthelifedidn'tdiewhenthe4ml/kgserumwasinjectedaf—terinjectingthe10mins.(4)ItwasfoundthattheZaocysdhumnadesserumhadnoob
8、viouspoisonoussideeffectonthemousesifinfectingtheZaocysdhumnadesserumtothesmallratsindifferentdensity.ConclusionZaocysdhumnadesserumhasthedetoyigicationontheVenomofNajanajakaonthia
