子宫颈高级别上皮内瘤变患者锥切术后切缘阳性的处理及预后探讨-妇产医学论文

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1、子宫颈高级别上皮内瘤变患者锥切术后切缘阳性的处理及预后探讨-妇产医学论文子宫颈高级别上皮内瘤变患者锥切术后切缘阳性的处理及预后探讨陈冰亚浙江大学医学院附属妇产科医院，浙江杭州310006[摘要]目的探讨子宫颈高级别上皮内瘤变锥切术后切缘阳性的处理及预后，总结治疗经验。方法以子宫颈高级别上皮内瘤变患者锥切术后切缘阳性再行手术治疗的228例作为研究对象，根据第2次术后病理结果将研究对象分为病变残留和无残留两组，对两组患者相关因素进行比较分析。结果病变无残留者133例，占58.33%，残留者95例，占41.67%，两组患者年龄差异无统计学意义（P＞0.05）

2、，首次手术方式、病变级别、阳性切缘病变级别、阳性切缘部位、HPV差异有统计学意义（P＜0.05）。结论术前HPV高拷贝、病变级别高、特别是原位癌、阳性切缘位于颈管端的患者病变残留高风险，需行再次锥切或严密随访。切缘部位为原位癌者建议扩大子宫切除。具体治疗方案需结合患者意愿、生育要求、随访条件而定。关键词子宫颈上皮内瘤变；锥切术；切缘阳性[中图分类号]R725[文献标识码]A[文章编号]1674-074２（２０１4）04（c）－０021-03DiscussionontheTreatmentofPositiveMarginforPatientswithCe

3、rvicalIntraepithelialNeoplasiaafterConizationandthePrognosisCHENBingyaWomen’sHospital，SchoolofMedicine，ZhejiangUniversity，Hangzhou，ZhejiangProvince，310006，China[Abstract]ObjectiveToinvestigatethetreatmentofpositivemarginforpatientswithcervicalintraepithelialneoplasiaafterconizat

4、ionandtheprognosis，andsummarizetheexperienceoftreatment.Methods228casesofcervicalintraepithelialneoplasiapatientswithpositivemarginafterconizationunderwentsurgicaltreatmentforthesecondtimewereselectedasthesubjects.Basedonthesecondpostoperativepathologyresults，thesubjectsweredivi

5、dedintotwogroupsofresiduallesionsandnoresidue，andtherelatedfactorsoftwogroupsofpatientswerecomparedandanalyzed.ResultsThelesionswithoutresidualin133cases，accountingfor58.33%，residualin95cases，accountingfor41.67%；thedifferencebetweentwogroupsinagewasnotstatisticallysignificant(P0

6、.05)，butthedifferencesbetweenthegroupsinthefirstmodeofoperation，pathologicalgrade，positivemarginlesiongrade，positivemarginpart，andHPVwerestatisticallysignificant(P0.05).ConclusionPreoperativeHPVhighcopy，highgradelesions，especiallycarcinomainsitu，positivemarginsinthenecktubeendof

7、thelesionsinpatientswithresidualhighrisk，needthesecondconizationorclosefollow-up.Expandinguterusexcisionissuggestedforthepatientswhosecuttingedgepartiscarcinomainsitu.Thespecifictreatmentshouldbecombinedwiththepatient’swish，fertilityrequirementsandfollow-upconditions.[Keywords]C

8、ervicalintraepithelialneoplasia；Conization；Posi