尼莫地平对脑出血患者血中白细胞介素6和肿瘤坏死因子α含量的影响

《尼莫地平对脑出血患者血中白细胞介素6和肿瘤坏死因子α含量的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、尼莫地平对脑出血患者血中白细胞介素6和肿瘤坏死因子α含量的影响作者：何志聪，李文娟，李战辉，贺鹏【摘要】目的观察脑出血患者血中白细胞介素6(IL6)和肿瘤坏死因子α(TNFα)含量的变化及钙离子拮抗剂尼莫地平对其的影响。方法将65例脑出血患者分为尼莫地平治疗组(33例)和常规治疗组(32例)。采用电化学发光法测定两组患者治疗前及治疗后10天血清中IL6、TNFα含量。并与正常对照组(30例)进行比较。同时，对两疾病组患者生活质量进行比较。结果尼莫地平治疗组和常规治疗组治疗前IL6、TNFα明显升高，与正常对

2、照组比较差异均有显著性(P均＜0.01)；治疗前尼莫地平治疗组和常规治疗组间IL6和TNFα差异均无显著性(P均＞0.05)；治疗后10天，常规治疗组与尼莫地平治疗组IL6、TNFα均较治疗前明显降低(P均＜0.01)，尼莫地平治疗组较常规治疗组降低更明显(P均＜0.01)。尼莫地平治疗组较常规治疗组的生活质量明显提高(P＜0.01)。结论脑出血患者早期血清中IL6、TNFα含量明显升高，尼莫地平可有效降低其含量，提高患者生活质量。【关键词】脑出血；尼莫地平；白细胞介素6；肿瘤坏死因子【Abstract】Obj

3、ectiveToobservetheserumchangesof9Interleukin6(IL6)andtumornecrosisfactorα(TNFα)inpatientswithcerebralhemorrhageandtheeffectofnimodipineonit.Methods65casesofcerebralhemorrhageweredividedintonimodipinetreatmentgroup(33cases)andconventionaltreatmentgroup(32cases).S

4、erumIL6,TNFαcontentintwogroupsweredetectedbyElectrochemicalluminescencedeterminationbeforetreatmentand10daysafterthetreatment,thencomparedwiththenormalcontrolgroup(30cases).Thequalityofpatientslifewerecomparedintwogroupsatthesametime.ResultsTheserumIL6andTNFαweres

5、ignificantlyincreasedintheNimodipinetreatmentgroupandtheconventionaltreatmentgroupbeforethetreatment,therewassignificantdifferencecomparedwithnormalcontrolgroup(P＜0.01).SerumIL6andTNFαwerenotsignificantlydifferentbetweennimodipinetreatmentgroupandconventionaltreat

6、mentgroupbeforethetreatment(P＞0.05);buttheysignificantlydecreasedafter10daystreatment(P＜0.01),especiallyinthenimodipinetreatmentgroup.Thequalityoflifesignificantlyincreasedinnimodipinetreatmentgroup,comparedwiththeconventionaltreatmentgroup(P＜0.01).ConclusionSerumIL

7、6andTNFαwassignificantlyincreasedinpatientswithcerebralhemorrhageattheearlystage,butnimodipinecan9reducetheircontentandimprovethepatientsqualityoflife.【Keywords】cerebralhemorrhage;nimodipine;interleukin6;tumornecrosisfactorα脑出血是神经科中最常见的疾病，致残率和死亡率均较高。随着对脑出血发病后病理生理

8、变化及治疗方法研究的逐渐深入，发现炎性细胞因子可介导广泛的组织损伤，在损伤反应中起着重要作用，可以介导脑卒中后的许多病理生理反应，如发热、白细胞聚集、血管内皮渗透性增加等，从而与神经细胞损伤密切相关。而且目前认为炎性细胞因子可诱导中枢神经系统中某些重要的神经毒性分子的释放，导