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1、小儿支原体肺炎中医证候与TH细胞相关性研究作者：姜永红,姜之炎,马晶,胡鹏,张婧延,石李,徐彬彬【摘要】目的探讨TH1、TH2、TH17的效应因子干扰素-γ(IFN-γ)、白细胞介素(IL)-4、IL-17与小儿肺炎支原体肺炎(MPP)中医证型的关系。方法选取55例MPP住院患儿,根据症状体征进行中医辨证分型,检测血清IFN-γ、IL-4、IL-17含量,与33例正常组儿童进行比较。结果55例MPP中,风热闭肺证25例,痰热闭肺证3例,痰瘀互阻证11例,脾虚痰蕴证16例。MPP患儿血清IFN-γ、IL-4、IL-17较正常组儿童均升高,IL-4、IL-17显著升高(均P<0.
2、01),IFN-γ升高无统计学意义。痰热闭肺证的血清IFN-γ、IL-4含量均高于其余3组(P<0.01);脾虚痰蕴证IL-4低于其余3组(P<0.01);IL-17含量各证型之间差异无统计学意义。结论MPP患儿中医证候与TH细胞具有相关性,可为不同证型分期论治提供较客观的免疫学指标。【关键词】小儿;支原体肺炎;中医证候;TH细胞;相关性 Abstract：ObjectiveTostudyTCMsyndromescharacteristicofmycoplasmapneumoniaepneumonia(MPP)andexploreitsrelationshipwithT
3、H1,TH2,TH17cells’effectfactorsIFN-γ,IL-4,IL-17.MethodFifty-fivecasesofMPPhospitalized10children,deteminedTCMsyndromedifferentiationaccordingtosymptomsandsigns,weredetectedserumlevelsofIFN-γ,IL-4,IL-17,with33normalchildrenasnormalcontrolgroup.ResultsIn55cases,therewere25casesofthewind-heatblock
4、ingthelungsyndrome,3casesofthephlegm-heatblockingthelungsyndrome,11casesofthebindingofphlegmandbloodstasissyndrome,16casesofthephlegmaccumulateduetospleendeficiencysyndrome.SerumIFN-γ,IL-4,IL-17levelincreasedinMPPpatientscomparedwithcontrolgroup,withsignificantdifferenceinIL-4andIL-17(P<0.0
5、1),whilenodifferenceinIFN-γlevel.SerumlevelsofIFN-γandIL-4insyndromeofphlegm-heatblockingthelungwerehigherthantheotherthreesyndromessignificantly(P<0.01).SerumlevelofIL-4insyndromeofphlegmaccumulateduetospleendeficiencywaslowerthantheotherthreesyndromessignificantly(P<0.01).Therewasnodif
6、ferenceinIL-17levelsamongthevarioussyndromes.ConclusionTheTCMsyndromeandTHcellsofMPPchildrenhaverelativity,whichprovidesmoreobjectiveimmunologyindexsignfortheMPPclinicaltreatmentbasedonsyndromedifferentiation. Keywords：children;mycoplasmapneumoniae10pneumonia;TCMsyndrome;THcells;correlation
7、肺炎支原体(mycoplasmapneumoniae,MP)是引起小儿社区获得性肺炎的常见病原,其发病机制与免疫高度相关。目前对肺炎支原体肺炎(MycoplasmaPneumoniaePneumonia,MPP)与TH细胞的关系正处于探索阶段,尤其是新发现的TH17细胞,对其在发病中作用的研究,将为治疗提供新的思路。为此,我们对MPP不同中医证型的TH1、TH2、TH17细胞的效应因子,血清干扰素-γ(IFN-γ)、白细胞介素(IL)-4、IL-17进行了检测,探讨T
