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1、克林霉素诱导型耐药葡萄球菌体外抗菌活性研究 作者:徐修礼仇王斌孙怡群樊新【摘要】 目的了解医院内感染可诱导克裣林霉素耐药葡萄球菌的发生尺率及常用抗菌药物对葡萄球叙菌的体外抗菌活性和联合药敏实验。方法细菌鉴定应用訇VITEK全自动细菌鉴定舡分析系统;药敏试验采用K哒B纸片法和琼脂平板稀释法芯,按CLSI规定的标准进行;用D试验检测可诱导图克林霉素耐药的发生率。结勿果XX年7月至XX年4月端从临床各种感染标本中分离得到113株葡萄球菌,其棺中iMLSB表型(D试盟验阳性)占%;MSB表型泥(红霉素R,克林霉素S)遴占%;cMLSB表型(红奎霉
2、素R,克林霉素R)占%冶;红霉素耐药克林霉素敏感轳表型葡萄球菌58株中D试挡验阳性率为%;D试验阳赔性葡萄球菌对万古霉素、左篮氧氟沙星、阿米卡星、头孢埃唑林的MIC90分别为、扰、、16(mg/L),万拉古霉素与左氧氟沙星、阿米屏卡星、头孢唑林联合药敏结果MIC90均为(mg/腐L)。结论医院内感染诱导θ型克林霉素葡萄球菌的发生弄率已越来越高,临床应根据细菌实验室的耐药表型检测淅合理应用抗菌药物。【关刈键词】 葡萄球菌;克林霉娠素;红霉素;抗菌药物;Dm试验;联合药敏试验;耐苇药性ABSTRACT 脏Objective Toinvesti
3、gatet胚heincidenceoぜ9/9finduciblecl⒘indamycinresistantstaph述ylococcusinnosocomialinfIection,andan俣alyzeinvitro讫activityofth尴eroutineanti苠biotics(alon秫eorincombina呗tion)against刎staphylococcus. Methods 椭UseautomaticsystemVITEKt祆oidentifyand珞analyzetheba氆cteria;Kirby倜Baucerm
4、etho縻dandagardilu刀tionmethodtodetectdrugsu飑sceptibility九followingCLSIstandards;a项ndDTesttode豆tecttheincid憋enceofinduci佝bleclindamyc舾inresistantΜstaphylococc嚣us. Results 穆Inthe113stra俗insofstaphylococcusisola燔tedfromtheva尔riousclinica潢lsamplesduri亩ngJuly,XXand谌April,XX,amo
5、冽ngiMSB(DTestispositive.),MSB(ERR,C狺LS)andcMLSB瘠(ERR,CLS)p唠henotypeswer鲸e%,%and%resp积ectively.The朵positiveinci义denceinDTesビtwas%with58samplesofstapㄟhylococcuswh碣ichwassuscep艹tibletoclindamycinwhiler撼esistanttoer鲍ythromycin.T耐heMIC90ofvan滨comycin,levo碧floxacin,ami折kac
6、inandcefa冷zolinagainst麽Dtestpositi得vestaphylococcuswere,,,1羹6mg/Lrespect掠ively.TheMIC乒90ofcombined阙drugsensitiv⑺ityresultofl淳evofloxacin,巷amikacin,cef黝azolinwereal豢lmg/Lwhencom禧binedwithvan^comycin.Conc缟lusions Thei缈ncidenceofin兰fectionwiths7taphylococcu囹swasgrowing,襞whichwa
7、sposs习ibletoinduce熙drugresistan梓cetoclindamyцcininnosocom睿9/9ialinfections.Theclinica棺luseofantimicrobialagentshouldfollow焚theinstructi幂onofthedrugr钐esistancephe哒notypegivenbtythebacteria爻llaboratory.坐KEYWORDS Staphylococcus菽; Clindamyci曦n; Erythromy铧cin; Antimic铮robialage
8、nt; DTest; Com昨biningdrugsu渲sceptibility膪test; Drugre传sista