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1、Ｔｈｅ Ｅｆｆｅｃｔ ｏｆ Ｈｕａｎｇ Ｑｉ ｃｏｍｂｉｎｅｄ Ｃｈｕａｎｘｉｏｎｇｑｉｎ Ｉｎｊｅｃｔｉｏｎ ｉｎ ｔｈｅ ｒａｔ ｍｏｄｅｌ ｏｆ Ｑｉｘｕｘｕｅｙｕ ａｆｔｅｒ ｃｅｒｅｂｒａｌ ｉｓｃｈｅｍｉａ ｏｎ Ｃｘ４３ ｅｘｐｒｅｓｓｉｏｎ Ａｂｓｔｒａｃｔ Object:BasedonChinesemedicineandmodernmedicineaboutthefocalcerebralischemiainetiology,pathogenesisandtreatmentmethod,thepaperintendstoevaluate
2、theneurologicaldeficitscoreofexperimentalratsafterfocalcerebralischemiaandmeasuretheexpressionofCx43gapjunctionproteinsoastoverifytheguidingroleoftheYiqihuoxuemethedintreatinginincompletebloodofbureaucookingstovenaturebrain.Also,thepaperdiscussestheprotectivemechanismofYiqihuoxue
3、drugsincuringincompletebloodofbureaucookingstovenaturebrain.Methods:theexperimentstartsamong84healthySDrats(42malesand42females)afterone-week-longadaptivefeeding.Firstly,accordingtotheirweightandtheprincipleofsimilarbehavioralscore,theexperimentalratsarerandomlydividedinto7groups
4、of12,namely,shamoperationgroup,modelgroup,HuangQicombinedChuanxiongqingroup(treatmentgroup),andthelasttwogroupsarefurtherdividedinto3groups:last6h,12h,24htimethebrainlacksforblood.Then,beginningwithQixuxueyumodelfor10days.Onthe11thdaysofexperiment,shamoperationgroupandmodegroupsw
5、eregivenintraperitonealinjectionofsaline,2ml/only;HuangQiandChuanxiongqininjectiongroupsweregivenHuangQi7.2g/kg,intraperitonealinjection;Chuanxiongqin18.0mg/kg,intraperitonealinjection.Focalcerebralischemia,respectively,beforesurgeryandpreoperative12h30mineachinjectionof1,afteraf
6、urtherinjectionof1every12huntilthelastgroupofratswerekilled.Iffocalcerebralischemiamodelssuccessful,thenscoretherats’neurologicalbehavioraftertheratsareawakened,andtakebrainsamplesat6h,12h,24hrespectively,andanalyzetheCx43expressionbyimmunohistochemicalmethod.Result:HuangQicombin
7、edChuanxiongqininjectioncanreducecerebralischemiainCx43gapjunctionproteinexpression,andreducethedegreeofneurologicaldeficits.The6hneurologicaldeficitoftreatmentgroup,whencomparedwiththemodelgroup,therearenosignificantdifferences(P>0.05));Cx43proteincomparedwiththemodelgroupweresi
8、gnificantlydifferent(P<0.05).The12hneuro
