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时间:2018-10-30
《毛细胞型星形细胞瘤的临床病理特征的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、毛细胞型星形细胞瘤的临床病理特征的临床研究吕晶1王成鑫2陈琼霞2刘丽江2通讯作者1.长江航运总医院武汉脑科医院病理科湖北武汉430000;2.江大病理诊断所组织病理诊断室湖北武汉430053【摘要】目的:探讨毛细胞型星形细胞瘤的临床病理特征。方法:回顾性分析2例毛细胞型星形细胞瘤患者的临床资料。结果:木组2例均为男性,年龄分别为1岁及2岁。发病部位位于右侧小脑和后颅窝。木组例1镜下具有双相性的特点,由比例不等的致密1X(含Rosenthal纤维)和疏松1X(嗜酸性颗粒小体>相互交替组成,肿瘤细胞呈梭形,有毛发样的突起的特点。例2镜下于大量粘液背景中见双极性的梭形细胞,未见Rosenthal纤
2、维,其内血管增生。免疫标记显示,2例瘤细胞均阳性表达胶质纤维酸性蛋白(GFAP)、Vimentin蛋白(Vimentin)及S-100蛋白(S-100),而神经元特异性烯醇化酶(NSE)只在例1的瘤细胞中表达,2例Ki-67阳性率均<l%。结论:毛细胞型星形细胞瘤病理上分为毛细胞型星形细胞瘤和毛细胞粘液样型星形细胞瘤,均好发于儿童和青少年。毛细胞型星形细胞瘤的组织学特征是双相型,含有Rosenthal纤维和嗜酸性小体成分。毛细胞粘液样型星形细胞瘤是由双极性的梭形细胞组成,间质内含宥大量的黏液。【关键词】毛细胞型星形细胞瘤;临床病理;毛细胞粘液样型星形细胞瘤【中图分类号1R739.4【文
3、献标识码】B【文章编号】1674-8999(2015)8-0274-03Clinicopathologicalfeatuersofpilocyticastrocytoma(reportof2cases)LVJingl,WANGCheng-Xing2,CHENQiong-Xia2,LIULi-Jiang2(1.GeneralHospitaloftheYangtzeRiverShippingWuhanBrainHospital,Wuhan430000,China;2.PathologicaldiagnosisofJianghanUniversity,Wuhan430053,China;)[Abs
4、tract]Objective:ToexploretheClinicopathologicalfeatuersofpilocyticastrocytomas.Methods:Theclinicaldataoftwopilocyticastrocytomaspatientswereanalyzedretrospectively.Results:Allthe2casesoccurredinmalepatientsattheageof1yearsand2yearsrespectively.Exampleonewaslocatedinthethirdcerebellar,whileexampletw
5、owaslocatedattheposteriorfossa.Histologically,intheonecase,thetumorwascomposedofbiphasicpatterncells.Pilocyticastrocytomacharacteristicallycontainedalternativedenselypackedareas(containrosenthalfibers)andlooselypackedarea(containeosinophilicbody).Thetumorcellshavefusiformshapeandhair-likeprojection
6、s.Histologically,seealotofmucusinthebackgroundofbipolarspindlecells,norosenthalfiber.Thereareinnervascularproliferation.Inthetowcases,immunohistochemicalshowedglialfibrillaryacidicprotein(GFAP),Vimentinprotein(Vimentin)andS-100protein(S-100)inneoplasticcellwerepositivity.Butneuronspecificenolase(NS
7、E)expressionintheonecase.ThepositiverateofKi-67nuclearwas1%inneoplasticcell.Conclusions:Histologically,pilocyticastrocytomawascompsedofpilocyticastrocytomasandpilomyxoidastrocytoma.Thetwotypesofpilocyticast
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