药学毕业论文纳米珍珠粉对大鼠深ⅱ°烧伤创面愈合的影响

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1、XX大学毕业论文纳米珍珠粉对大鼠深II°烧伤创面愈合的影响2014年6月25日作者：崔淑芳，郝光荣，汤球，孙伟，曹平【摘要】目的研究纳米珍珠粉对大鼠深II。烧伤创面愈合的影响并与微米珍珠粉在烧伤愈合中进行药效比较。方法纳米珍珠粉、微米珍珠粉(0.5g/只)分别与甘油按1:1配制成混合液。以微米珍珠粉组与自然愈合组作对照，纳米珍珠粉组为实验组。测定大鼠14%深II。烫伤后7、15、21天的创面愈合率、创面组织学观察以及皮肤疑脯氨酸的含量。结果纳米珍珠粉组创而愈合率较微米珍珠粉组、自然愈合组高(P<0.05或PV0.01

2、)；烧伤后3天各组皮肤耗脯氨酸含量均低于正常(PV0.01),纳米珍珠粉组减少程度小于其他组；伤后5天各组HP含量有所恢复，尤以纳米珍珠粉组显著高于自然愈合组及微米珍珠粉组；10天后各组明显升高，而纳米珍珠粉组HP含量的升高差界有非常显著性(PV0.01)。结论纳米珍珠粉可以促进大鼠深II。烧伤创而的愈合，其愈合作用明显高于微米珍珠粉(P<0.05)o【关键词】纳米珍珠粉；微米珍珠粉；烧伤；羟脯氨酸[Abstract]ObjectiveTostudytheefficiencycomparisonbetweennano

3、andmicropearlpowderfortreatmentofdeepII°skinscaldsinrats.MethodsNanoandmicropearlpowder(0.5geachrat)aremixedwithglycerol(1:l).Withthemicropearlpowdergroupandthenonnalhealinggroupasthecontrol,nanopearlpowderwereusedasdrugonthedeepII°skinscaldsofratsintheexperime

4、ntalgroups.Woundhealingrateswasmeasuredat7,15,21dayspost-injury；andthecontentofhydroxyproline(HP)weredetectedalso.ResultsWoundhealingratesofthenanopearlpowdergroupwerehigherthanthatofthemicropearlpowdergroupandthenormalhealinggroup(P<0.05orP<0.01).Atthe3thdaypo

5、st-injury,thecontentofHPineverygroupwerelowerthanthatinthenormalgroup(P<0.01),whilethedecreaseinthenanopearlpowdergroupwasslightthanthoseinothergroups.Atthe5thdaypost-injury,thecontentofOHPrecoveredtosomeextent,withasignificantlyhigherelevationinthenanopearlpow

6、dergroupthanthoseinothergroups.Atthe10thdaypost-injury,evidentHPincreasewasfoundineverygroup,withastatisticalsignificanthigherelevationinthenanopearlpowdergroup(P<0.01).ConclusionNanopearlpowdercouldpromotethewoundhealingofdeepII°skinscaldsinratssignificantly,i

7、t'shealingwasmorehigherthanthatofmicronpearlpowde匚【Keywords】nanopearlpowder；micropearlpowder；scald；hydroxyproline(HP)Thisresearchistostudythewoundhealingefficacyofnanopearlpowderintreatmentofdeep11°skinscaldsinratsandcomparethefunctionwiththoseofmicronpearlpowd

8、er.1Materialandmethods1.1Pearlpowder(ZhejiangFenixPharmaceuticalCo,Ltd),nanoandmicropearlpowder(0.5geachrat)aremixedwithglycerol(1:1).Dermalhydroxyprolincdetectionkit(Nanjin