简化调强放疗同步卡培他滨治疗直肠癌术后复发临床观察

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1、（临床应用研老/迫蓉》简化调强放疗同步卡培他滨治疗直肠癌术后复发临床观察张培良张佃富山东省临沂市浙水中心医院肿瘤科，山东沂水276400%【摘要】目的：观察直肠癌术后复发总者简化调冬放疗(sIMRT)同步卡培他潦化疗的近期疗效和不良反应。方法：33例直肠癌术后复发患者均行slMRTC先行盆粒淋巴引流区及直肠周国放疗(45〜50)Gy/(25f・5w〉，复发病灶局部加量18〜20Gy,(1・8〜2.0)Gy/次，5次/周，总剂董达63〜70Gy],并同步卡培他淇化疗(1000mg/m2,从放疗第1夭开始•连服14d,休息7d为】个周期，放疗期间口服2个周期〉.放疗

2、结束后行同方案巩固化疗2个周期。结果：全部总者均完成治疗，33例患者中CR5例(15.2%),PR20例(60.6%),NC6例(1&2%),PD2例(6.1%),总有效率75.8%.血清CEA下降50%并维持个月者21例(84.0%).治疗后临床症状改善和明显好转29例(87.9%)。主要不良反应是血液学毒性、消化道反应、急性膀胱炎和手足综合征等•均可耐受.结论：调冬放疗联合卡培他滨同步化疗治疗直肠癌术后复发患者•不良反应轻，近期疗效确切•值得在临床上进一步探讨应用.【关键词】简化调强技术/放射疗法'立肠癌/治疗'卡培他淇/化学治疗'近期疗效中华肿和防治杂志・

3、2012,19(14),1103-1105Short-termefficacyofsimplifiedintensity-modulatedradiationtherapycombinedwithCapecitabineforpostoperativerecurrentrectalcarcinomaZHANGPei-liang,ZHANGDian-fuDepartmentofMedicalOncology»YishuiCentralHospitaltYishui276400,P.R・ChinaLABSTRACT]OBJECTIVE：Toevaluatethesh

4、ort-termefficacyofsimplifiedintensitymodulatedradiationtherapy(sIMRT)combinedwithCapecitabineforpostoperativerecurrentrectalcarcinoma^MKIUODS：Thirty-threcpatientswithpostoperativecurrentrectalcarcinomareceivedsIMRT(pelviclymphaticdrainageareaandaroundtherectumreceivedradiotherapywith

5、45—50Gy/25f•5wtthelocallyrecurredlesion18—20Gy.1.8—2・0Gy/f.5timesaweek,totaldose63—70Gy).SynchronouschemotherapywithCapecitabine(1000mg/m2orallyfromthefirstdayofradiotherapy•1cyclewith14daysofadministration•7daysofrest»totally2cyclesduringtheradiotherapy).Another2cyclesofsamechemothe

6、rapyaftertheendofradiotherapy.RESULTS：Allthepatientscompletedtheregimesafely.Thecompleteremissionratewas15.2%>partialremissionrale60.6%,stablediseaseratewas1&2%*andtheprogressivediseaseratewas6.1%•Thetotalefficiencyrate(CR+PR)was75.8%♦andtheclinicalsymptomsimproved87.9%.Thepatientswi

7、thCEAdccrcaseingformorethan50%andlastingformorethan1monthwere21cascs<84.0%)・Themainsideeffectscouldbetolerated.CONCLUSION:sIMRTcombinedwithCapecitabineforpostoperativelocalrecurrenceofrectalcancerissafewithmildadversereactions•convenientadministration•confirmedshort-termefficacyandwo

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