tap基因多态性与变应性鼻炎相关性研究

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1、英文摘要visible，Asp／Aspif307and429bpbandswerevisible，andGly／Glyif180and429bpbandswerevisible．ThreeTAP1genotypes(Ile／Ile，Ile／ValandVal／Val)werefoundatcodon33．TwoTAP1genotypes(Asp／Asp，Asp／Gly)wereseenatcodon637．TheGly／GlygenotypewasnotfoundinbothARandcontro

2、ls．4Resultofstatisticalanalysis：IIandDDwerethemostcommongenotypeoftheTAPlcodon3and637inboththeARgroupandcontrolgroup．TheTAP1333wasfoundhavestatisticalsignificanceascomparedwiththecontrolgroup(P<0．05)．nostatisticalsignificancewasobtainedinthelatter(P>O

3、．05)．IandDwerethemostcommonalleleoftheTAPlcodon333and637inboththeARgroupandcontrolgroup．TheTAP1333wasfoundhavestatisticalsignificanceascomparedwiththecontrolgroup(P<0．05)．nostatisticalsignificancewasobtainedinthelatter(P>O．05)．Conclusions：Inconclusion

4、，thisstudyshowedameaningfulassociationbetweenARandTAP1333polymorphism．butnotTAP1637．Therefore，itissuggestedthataTAP1333genepolymorphismmaybeallimportantfactorinARpathogenesis．TAPassusceptibility／protectiVegeneofARaffectedbytheobjectivefactorssuchassel

5、ectionofpatients，differentpopulation，regionalenvironment．Anditsspecificgeneticsignificancehastobefurtherclarified．Keywords：Rhinitis；Allergic；Transportersassociatedwith6英文摘要antigenprocessing；Genepolymorphisms．7英文摘要AbbreviationTAPMHCHLAAR英文缩写FullEnglish

6、NametransporterassociatedantigenprocessingMajorhistocompatibilitycomplexHumanleukocyteantigenAllergicRhinitisDEPCdiethypyrocarbonateEBEDTAetudiumbromidedisodiumethylenediaminetetraacetatesTristrishydroxymethylaminomethaneTAEAI之MSPCRODslgEtris．acetas．E

7、DⅨamplificationrefractorymutationsystempolymerasechainreactionopticaldensitySpecificImmunoglobulinEChinese抗原处理相关转运蛋白主要组织相容性复合体人类白细胞抗原变应性鼻炎焦碳酸二乙酯溴化乙锭二水乙二胺四乙酸二钠三羟甲基氨基甲烷E缓冲液增扩阻碍突变系统聚合酶链反应光密度特异性免疫球蛋白E8河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位

8、论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权归河北医科大学所有。否则，承担相应的法律责任。研究生签铆5勒弛张嘶二◇7研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自