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时间:2019-02-03
《体外诱导骨髓间充质干细胞向神经细胞分化的研究进展》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、现代肿瘤医学2015年04月第23卷第7期MODERNONCOLOGY,Apr.2015,VOL.23,NO.07·1027·[21]WashburnT,SchweighofferE,GridleyT,etal.Notchactivityin-[24]RealPJ,ToselloV,PalomeroT,etal.Gamma-secretaseinhibi-fluencesthealphabetaversusgammadeltaTcelllineagedecisiontorsreverseglucocorticoidresistancein
2、Tcellacutelymphoblastic[J].Cell,1997,88(6):833-843.leukemi[aJ].NatMed,2009,15(1):50-58.[22]WengAP,NamY,WolfeMS,etal.Growthsuppressionofpre-T[25]SchottAF,LandisMD,DontuG,etal.Preclinicalandclinicalacutelymphoblasticleukemiacellsbyinhibitionofnotchsignalingstudiesofgammasec
3、retaseinhibitorswithdocetaxelonhuman[J].MolCellBiol,2003,23(2):655-664.breasttumor[sJ].ClinCancerRes,2013,19(6):1512-1524.[23]KolbEA,GorlickR,KeirST,etal.Initialtesting(stage1)bythe[26]WuY,Cain-HomC,ChoyL,etal.Therapeuticantibodytarge-pediatricpreclinicaltestingprogramofR
4、O4929097,agamma-tingofindividualNotchreceptor[sJ].Nature,2010,464(7291):secretaseinhibitortargetingnotchsignaling[J].PediatrBlood1052-1057.Cancer,2012,58(5):815-818.(编校:贺鲁宁)体外诱导骨髓间充质干细胞向神经细胞分化的研究进展郑蕊,廖承德,丁莹莹Researchprogressofbonemarrowmesenchymalstemcellswereinducedintone
5、rvecelldifferentiationinvitroZhengRui,LiaoChengde,DingYingyingDepartmentofRadiology,TheThirdAffiliatedHospitalofKunmingMedicalUniversity,TheTumorHospitalofYunnanProvince,YunnanKunming650118,China.【Abstract】Becauseoftheabilityofmulti-directionaldifferentiation,bonemarrowme
6、senchymalstemcellsarewide-lyused,especiallyinthetreatmentofneurodegenerativediseases.Alotofmethodscanbeused,alsotherearelotsoftraditionalChinesemedicineasinducers.Currentdifferentiationmethodsaredividedintotwocategories:chemicalder-ivationandtheculturetogether.Differentin
7、ductionmethodsleadtodifferentresults.Inthisoverview,bonemarrowmesenchymalstemcellswereinducedintonervecelldifferentiationinvitroandresearchprogresswerepresented.【Keywords】bonemarrowmesenchymalstemcells;inductionanddifferentiation;nervecell;researchprogressModernOncology20
8、15,23(07):1027-1029【指示性摘要】骨髓间充质干细胞因其具有多向分化的能力,被广泛应用于临床中,特别是用于治疗神经退行性疾病。体外诱导分化骨髓间充质干细胞的方法很多,也有很多中
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