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1、提要目的：观察固本通络方治疗2型糖尿病冠心病稳定型心绞痛的临床疗效，并初步探讨其发生作用的机制与目前的进展研究。方法：随机选择60例2型糖尿病冠心病稳定型心绞痛脾肾两虚，痰浊阻滞证患者，随机分为A、B两组，每组30例。A组为治疗组，服用达美康30mgQD，加用固本通络方；B组为对照组，服用芪参益气滴丸0.5gTid，以及服用达美康30mQD。治疗周期为两个月。结果：中医症状总疗效，治疗组总有效率为93.3%，对照组总有效率为70%，治疗组优于对照组（P＜0.05），稳定型心绞痛有效率，治疗组总有效率为90%，对照组总有效率为73.3%，治疗组优于对照组（P＜0.0
2、5），24h动态心电图疗效指标示，心肌缺血、心肌耗氧量及冠状动脉张力均改善，治疗组优于对照组（P＜0.05），结论：固本通络方能够显著改善2型糖尿病冠心病脾肾两虚，痰浊阻滞患者的临床症状与部分实验室指标，具有较好的临床效果，能够显著改善患者的生存质量。固本通络方为2型糖尿病冠心病稳定型心绞痛患者小血管病变的改善，即非介入治疗适应症的治疗和稳定型心绞痛的防治提供了新的思路和方法。关键词固本通络方；2型糖尿病冠心病；稳定型心绞痛；脾肾两虚，痰浊阻滞；临床研究GubentongluofangtothetreatmentofstableanginapectorisinCo
3、ronaryheartdiseasewithtype2DMclinicalresearchSpeciality:MedicineofTCMTutor:Prof.BaoPeirongAuthor:SunliangAbstractObjective:Toobservetheclinicaleffectofgubentongluofangtothetreatmentoftype2DMwithcoronaryheartdiseasewithstableanginaandtoinvestigateitsmechanismandtheroleofthecurrentprogr
4、ess.:Thenselect60patientswithtype2diabeteswithcoronaryheartdiseasewithstableanginapectorisspleenandkidneydeficiencyphlegmblockSyndrome,wererandomlydividedintotwogroups(A,B),30casesineachgroup.GroupAforthetreatmentgrouptakingtoDiamicron30mgQD,gubentongluofang.GroupBasthecontrolgroup,qi
5、shenyiqidiwan0.5gTid,aswellastakingtheDiamicron30mgQD.Thetreatmentcyclefortwomonths.Results:ThetotalefficacyofTCMsymptoms,treatmentgroup,thetotaleffectiveratewas93.3%,controlgroup,thetotaleffectiveratewas70%,thetreatmentgroupthanthecontrolgroup(P<0.05),stableanginapectorisefficiency,t
6、hetreatmentgroup,thetotalefficiency90%,controlgroup,thetotaleffectiveratewas73.3%,thetreatmentgroupthanthecontrolgroup(P<0.05),24hdynamicelectrocardiogramindicatedtheresultisthatMyocardialoxygenconsumptionandcoronaryarterytensionweresignificantlyimprovedtreatmentgroupthanthecontrolgro
7、up(P<0.05).Conclusion:gubentongluofangcansignificantlyimprovetype2diabeteswithcoronaryheartdiseasespleenandkidneydeficiency，phlegmblockingthepatient'sclinicalsymptomsandsomelaboratoryparameters,andhasgoodclinicaleffects,cansignificantlyimprovepatient'squalityoflife.gubentongluofangfor
8、theim
