深圳市2007年流感流行特征与病毒分子变异分析

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1、郑州人学2008届硕l学位论文英文摘要influenzavirusandinfluenzaePidemies.ReSUltS1.TheePide而ologiealeharaeteristiesofinfluenzainShenzhenin2007ThePereentageofILIinShenzhenshowsonepeakmainlydistributedinAPriltoJuly，whiehreaehesPeakat11.22%exceededthealertlineof10.86%duringtheweekendingof

2、June24，2007(week25).ThemajorityofILIdistributedinPeopleagedbelow15andaeeoutingfor72.97%.Thealertlinewaswithgoodsensitivityandseasonality，beingtimelyinfindingunusualvalue.50susPeetedinfluenzaouthreakswererePortedinShenZhenin2007and35outbreakswereeonfirmedbyPCR.Ofwhich

3、，29(58.0%)outbreakswerecausedbyinfluenzaAvirus，while6(12.0%)outhreakswereeausedbyinfluenzaBvirus.MostoftheoutbreaksoeeuredinPrimaryandmiddleschoolsandfrequentlydistributedfromMarehtoJune，aeeountingfor92.0%.2831sPeeimensweretestedforinfluenzavirusinShenzhenin2007，and3

4、43werePositive.Theisolatingratewas12.12%.TheProPortionsofinfluenzaHINI，H3NZandBviruswere3.50%，62.68%and33.82%，resPectively.ThePredominantstrainwasinfluenzaH3NZvirusfromJanuarytoJuneandB(丫妞magata)wasduringJulytoDevember.Themonthlyisolatingrateshowsaninereasingtrendand

5、reaehesthePeakinJune(28.38%)，andadeereasingtrendinthelatterhalfyear.WiththebaselineinformationwefoundthatthePredominantstrain即pearedbytums.Theserafrom828and872individualswereeollectedinShenzheninMarchandSePtember，resPeetively.ThelevelofH3NZantibodywashigh，andtheantib

6、odyPositveratewere65.82%and72.94%inMarehandSePtember，resPectively.WhilethePositiverateofinfluenzaHINI，B(Victoria)，andB(Yamagata)virusinMarehandSePtemberwere46.98%，43%，43.84%，21.90%，41.18%and21.67%，resPeetively.ThelevelofGMTofinfluenzaHINI，B(Vietoria)andB(、认magata)vir

7、uswerelowbesidesillfluenzaH3NZvirus.2.ThegenetievariationofHAIoftheinfluenzaviruseireulatinginShenzhenin2007PhylogenetieanalysisofinfluenzaH3NZviruswaseonsistentwiththehomologyofnueleitideeomParingwiththerefereneevi几ses.StrainsisolatedfromJanuarytoAPrilelusteredwith户

8、以JXDH/312/2006(H3NZ)，whichwasreeommendedbyChinaCDC.ThevirusesisolatedfromMaytoDeeember(aceountingfor89.30%)showaeloserrelationshiPt