应用瑞舒伐他汀对h型高血压合并急性冠脉综合征大鼠血管内皮功能的影响

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1、授予单位代码10089学号或申请号13093HebeiMedicalUniversity硕士学位论文在职科学学位应用瑞舒伐他汀对H型高血压合并急性冠脉综合征大鼠血管内皮功能的影响学位申请人：杨宝刚导师：王立新教授专业：内科学二级学院：沧州中西医结合医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医

2、科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。m研究生签名师签章：丨t:iF级学院领导•章：“‘“⑵r月}h河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除1文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。I研究生签名：御导师签章：&.1yi]年It,7?日目录中文摘要··············································

3、·······························1英文摘要·············································································3研究论文应用瑞舒伐他汀对H型高血压合并急性冠脉综合征大鼠血管内皮功能的影响前言·············································································6材料与方法································

4、····································7结果·············································································11附图·············································································12附表···································································

5、··········15讨论·············································································17结论·············································································20参考文献·······································································21综述血管内皮生长因子在心脑血管疾病

6、中的研究进展·················26致谢···················································································32个人简历·············································································33中 文 摘 要应用瑞舒伐他汀对H型高血压合并急性冠脉综合征大鼠血管内皮功能的影响摘要目的：给予大鼠灌胃瑞舒伐他汀，通过皮下注射异丙肾上腺素建立H型

7、高血压大鼠合并急性冠脉综合征模型，观察大鼠在急性冠脉综合征6小时后，血管内皮生长因子和不对称二甲基精氨酸的表达，探讨应用瑞舒伐他汀对改善血管内皮功能的可能机制，为临床应用提供可靠的实验依据。方法：本实验将雄性大鼠随机分为三组：正常SD大鼠设为正常对照组（NC组）、H型高血压建立急性冠脉综合征大鼠设为模型组（ACS组）、H型高血压大鼠给予瑞舒伐他汀干预后建立急性冠脉综合征模型设立为瑞舒伐他汀干预组（RCS组），每组保证8只大鼠。H型高血压模型采用自发性高血压大鼠喂食添加2%蛋氨酸的基础鼠粮。瑞舒伐他汀治疗组给予10mg/kg/d灌胃

8、，正常对照组及模型组大鼠灌服等容量的蒸馏水，连续4周。大鼠在实验期间自由进食水。4周后，内眦采血法测量大鼠血同型半胱氨酸、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇，利用皮下注射异丙肾上腺素法（30mg/kg）造急性冠脉综合模型，H