资源描述：
《早期沃勒变性中大鼠坐骨神经损伤的基因表达》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、NEURALREGENERATIONRESEARCHVolume7,Issue17,June2012www.nrronline.orgCitethisarticleas:NeuralRegenRes.2012;7(17):1285-1292.GeneexpressionprofilingoftheratsciaticnerveinearlyWalleriandegenerationafterinjury*****☆1,2111331DengbingYao,MeiyuanLi,DingdingShen,FeiDing,ShibiLu,QinZhao,Xi
2、aosongGu1JiangsuKeyLaboratoryofNeuroregeneration,NantongUniversity,Nantong226019,JiangsuProvince,China2SchoolofLifeSciences,NantongUniversity,Nantong226019,JiangsuProvince,China3KeyLaboratoryofPeople’sLiberationArmy,InstituteofOrthopedics,ChinesePLAGeneralHospital,Beijing100853,
3、ChinaAbstractWalleriandegenerationisanimportantareaofresearchinmodernneuroscience.AlargenumberDengbingYao☆,Ph.D.,ofgenesaredifferentiallyregulatedinthevariousstagesofWalleriandegeneration,especiallyJiangsuKeyLaboratoryofNeuroregeneration,Schoolofduringtheearlyresponse.Inthisstud
4、y,weanalyzedgeneexpressioninearlyWallerianLifeSciences,Nantongdegenerationofthedistalnervestumpat0,0.5,1,6,12and24hoursafterratsciaticnerveinjuryUniversity,Nantong226019,usinggenechipmicroarrays.Wescreenedfordifferentially-expressedgenesandgeneJiangsuProvince,Chinaexpressionpatt
5、erns.WeexaminedthedataforGeneOntology,andexploredtheKyotoDengbingYaoandMeiyuanEncyclopediaofGenesandGenomesPathway.ThisallowedustoidentifykeyregulatoryfactorsLicontributedequallytothisandrecurrentnetworkmotifs.Weidentified1546differentially-expressedgenesand21distinctwork.patter
6、nsofgeneexpressioninearlyWalleriandegeneration,andanenrichmentofgenesCorrespondingauthor:Qinassociatedwiththeimmuneresponse,acuteinflammation,apoptosis,celladhesion,iontransportZhao,Ph.D.,Professor,Keyandtheextracellularmatrix.KyotoEncyclopediaofGenesandGenomespathwayanalysisLab
7、oratoryofPeople’srevealedcomponentsinvolvedintheJak-STAT,ErbB,transforminggrowthfactor-β,TcellLiberationArmy,InstituteofOrthopaedics,ChinesePLAreceptorandcalciumsignalingpathways.Keyfactorsincludedinterleukin-6,interleukin-1,GeneralHospital,Beijingintegrin,c-sarcoma,carcinoembry
8、onicantigen-relatedcelladhesionmolecules,chemok
