特发性血小板减少性紫癜血小板参数的临床意义

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1、62010年2月第11卷第1期ChineseJournalofMedicalLaboratoryTechn01o．Feb2010．V01．11N0．1【检验与临床】【ClinicalLaboratoryTest】特发性血小板减少性紫癜血小板参数的临床意义CLINICALSIGNIFICANCEOFPLATELETANDCORRELATIVEPARAMETERSINIDIOPATHICTHROINBOCYTOPENICPURPURA李勇慕悦意李筱梅夏永辉张云霞田鹏杨佳或曹增(中国医学科学院北京协和医学院血液学研究所血液病医院，天津

2、300020)摘要[目的]探讨特发性血小板减少性紫癜患者(idiopathicthrombocytopenicpurpura，ITP)血小板及其参数检测的临床意义以及与预后的相关性。[方法]应用SysmexXE一5000全自动五分类血液分析仪检测81例不同类型血小板减少症患者，包括40例再生障碍性贫血(aplasticanaemia，AA)和41例特发性血小板减少性紫癜(ITP)病人治疗前后血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、大血小板比率(P—LCR)和血小板分布宽度(PDW)，并将检测结果

3、与正常对照组进行比较。[结果]初诊时ITP和AA患者的PIJ1、明显低于正常对照组(P<0．01)。(1)初诊时IrP患者PDW、MPV、P—LCR明显高于对照组和AA患者，差异均具有显著性(P<0．01)，而AA患者PDW、MPV、P—LCR低于对照组差异有统计学意义(P<0．01)；2、ITP患者缓解后PIJr明显上升，而PDW、MPV、P—LCR下降；AA患者缓解后PIJT、PDW、MPV、P—LCR均上升。ITP和AA患者缓解组与未缓解组比较有统计学意义(P<0．01)。[结论]血小板参数的检测对于明确血小板减少的病因、

4、病情判断及疗效观察其预后具有重要临床意义。关键词特发性血小板减少性紫癜；血小板参数ClinicalsignificanceofplateletandcorrelativeparametersinidiopathicthroinbocytopenicpurpuraYong，MuRu，LiXiaomei，eta1．InstituteofHematology，BloodDiseaseHospital，CAMSandPUMC，Tialfin300020，ChinaAbstract[objective]Toexploretheclinic

5、alsignificanceofplateletandcorrelativeparametersinidiopathicthroinbocytopenicpur-pura．[Methods]Atotalof81patientswiththromhocytopeniawerestudied，including41caseswithidiopathicthrombocytopeniapurpura(ITP)and40patientswithaplasticanaemia(AA)．Theplateletindicesincluding

6、platelettotal(PLT)，meanplateletvolume(MPV)，plateletdistributionwidth(PDW)andplateletlargercellratio(P—LCR)weremeasuredbySysmexXE一5000automatedbloodcellana-lyzer．Theplateletindicesinthesepatientsbeforeandaftertreatmentwerefurtheranalyzedandstatisticallycomparedwiththo

7、seofthecon—trois．[Results](1)Beforethetreatment，PIJTweresignificantlylowerinpatientswithITPandAAincomparisonwiththecontrolgroup(P<0．O1)．(1)MPV，PDWandP—LCRinpatientswithITPwereobviouslyincreasedthanthoseofthecontrolgroup(P<0．001)．Meanwhile，MPV．PDWandP—LCRinpatientswit

8、hAAwerereducedthanthoseofthecontrolgroup(P<0．001)．(2)Afterthetreat-ment，PLTwassignificantlyincreased，MPV，PDWandP—LCRwerereducedforc