MicroRNA Expression and Function in Cardiac Ischemic Injury

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1、J.ofCardiovasc.Trans.Res.(2010)3:241–245DOI10.1007/s12265-010-9168-8MicroRNAExpressionandFunctioninCardiacIschemicInjuryShiyongYu&GuohongLiReceived:30November2009/Accepted:21January2010/Publishedonline:23February2010#SpringerScience+BusinessMedia,LLC2010AbstractI

2、schemicheartdisease(IHD)ormyocardialischemiadevelopswhencoronarybloodsupplytomyocar-ischemiaisoneoftheleadingcausesofmortalityalloverdiumisreduced,eitherintermsofabsoluteflowrate(low-theworld.Thereisadefiniteneedfornewapproachestofloworno-flowischemia)orrelativet

3、oincreasedtissueimprovetherapiesanddiagnostics.Thepathologicalpro-demand(demandischemia).ThepathologicalprocesscessleadingtoIHDisassociatedwithanalteredexpressionleadingtoIHDisassociatedwithanalteredexpressionofofgenesthatareimportantforcardiacfunctions.Micro-gen

4、esthatareimportantforcardiacfunctions.MicroRNAsRNAs(miRNAs)haveemergedasoneofthecentral(miRNAs)haveemergedasoneofthecentralplayersinplayersregulatinggeneexpressionviadegradationorregulationofgeneexpressioninvariouscelltypesviatranslationalinhibitionoftheirtargetg

5、enes.Increasingdegradationortranslationalinhibitionoftheirtargetgenes.evidenceindicatesthatmiRNAsmayserveaspotentialThereisincreasingevidencethatdifferentialdownregula-diagnosticbiomarkersandinnovativetherapeutictargetsintionandupregulationofselectivemiRNAsintheh

6、eartseveralhumandiseasesincludingcardiovasculardisease.representsanimportantmechanismforcontroloftheHere,wereviewthelatestadvancesintheidentificationandexpressionofmyocardialischemia-relatedgenes.validationofmyocardialischemia-relatedmiRNAsandMicroRNAsareaclassof

7、highlyconserved,single-theirtargetgenesanddiscusstherolesofspecificmiRNAsstranded,noncodingsmallRNAs[1,2].Theyareproducedinregulatingischemia-relatedcardiacinjury,includingfromprimaryRNAtranscripts(pri-miRNAs),whichareapoptosis,fibrosis,arrhythmia,andangiogenesis

8、.transcribedfromgenomesbyRNApolymeraseII.Pri-miRNAs,generallyseveralthousandofnucleotideslongKeywordsMicroRNAs.TargetGenes.GeneExpression.andcontainingtheactiv