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《Nature-20120927-Supp-Chronic obstructive pulmonary disease》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、OUTLOOKCHRONICOBSTRUCTIVEPULMONARYDISEASE27September2012/Vol489/IssueNo.7417ensofmillionsofpeoplearoundtheworldfindCONTENTSitdistressinglydifficulttobreatheowingtoaTcombinationofemphysemaandchronicasthmaticS2HEALTHIMPACTbronchitis—adeadlyduoknownaschronicobstructiveBreathl
2、esspulmonarydisease(COPD).AcloserlookattheproblemofCOPDSmokingisthemostcommontriggerforCOPD,andweS4BIOCHEMISTRYhavemappedtheincidenceofsmokingandtheprevalenceAradicaltreatmentofCOPDintheUnitedStates,acountrywithfine-grainedShieldingthelungswithantioxidantsdataonbothphenome
3、na(pageS2).ButthereismoretoCoverart:NikSpencerS7PERSPECTIVECOPDthansmoking.EvidenceisemergingthatsomeHowcangeneticshelp?peoplemightbegeneticallysusceptibletothedisease(S7),EdwinK.SilvermanseeshopeforpatientsEditorialwhileresearchersarepickingaparttheinvolvementofHerbBrody,
4、S8DIAGNOSISMichelleGrayson,errantimmunecells(S15).TocatchakillerMaryCarmichael,NewtreatmentsforCOPDareindevelopment.HotareasEarlydetectiontoimprovetreatmentTonyScully,Davinaofpursuitinvolvecombinationsofagents,aswellasnovelDadley-MooreS10NUTRITIONdrug-deliverysystems(S16).
5、MostavailabletreatmentsonlyArt&DesignThevitaminDcomplexabateCOPD’sdebilitatingflare-ups.OnenewlineofenquiryWesFernandes,Candietarysupplementsabatethedisease?istostimulatetheproductionofantioxidantstoneutralizetheAlisdairMacDonald,S12DEVICESAndreaDuffyfreeradicalsthattrigge
6、rtheviolentbiochemicalcascadesthatArtificialinspirationleadtothelungs’deterioration(S4).IfthedamagewroughtProductionAlloptionsareontheoperatingtableDonaldMcDonald,isirreversible,artificiallungsmightbeanoption(S12).AndS15PERSPECTIVEKellyHopkins,Leonoratherearetantalizingear
7、lyresultsthatsuggestthatvitaminDDawson-Bowling,Clues,notconclusionssupplementscanatleastslowthelungs’deterioration(S10).YvonneStrongStevenR.DuncansummarizesthecaseNoremedyforCOPDwillbeeffectiveiftheconditionagainstCOPD–autoimmunityconnectionSponsorshipisnotproperlydiagnose
8、d.Indeed,toooften,thediseaseisWillPiper,YvetteS16THERAPEUTICSmistakenforother,lessserious
