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1、强力调脂，安全选择－贝特类在联合调脂治疗中的地位中南大学湘雅二医院赵水平调脂药物主要临床研究－他汀类1.DownsJRetal.JAMA1998;279:1615–22; 2.HoogwerfBJetal.Diabetes1999;48:1289–94; 3.SacksFMetal.NEnglJMed1996;335:1001–9; 4.TheLong–termInterventionwithPravastatininIschaemicDiseaseStudyGroup.NEnglJMed1998;339:1349–57; 5.Shep
2、herdJetal.Lancet2002;360:1623–30; 6.ALLHATCollaborativeResearchGroup.JAMA2002;288:2998–3007;研究预防类型发表年限治疗总人口糖尿病人群随访（年）AFCAPS/TexCAPS1一级1998洛伐他汀6,6051555.2(均值)PostCABG2二级1999洛伐他汀1,3511164.3(均值)CARE3二级1996普伐他汀4,1595865(中位数)LIPID4二级1998普伐他汀9,0147826.1(均值)PROSPER5混合2002普伐他汀5,
3、8046233.2(均值)ALLHAT–LLT6混合2002普伐他汀10,3553,6384.8(均值)4S7二级1994辛伐他汀4,4442025.4(中位数)HPS8混合2002辛伐他汀20,5365,9635(均值)ASCOT–LLA9混合2003阿托伐他汀10,3052,5323.3(中位数)CARDS10一级2004阿托伐他汀2,8382,8383.9(中位数)TNT11二级2005阿托伐他汀10,0011,5014.9(中位数)4D12混合2005阿托伐他汀125512554.0(中位数)荟萃分析13混合2005所有现有的他
4、汀类90,05618,6864.7(均值)他汀类主要试验7.ScandinavianSimvastatinSurvivalStudyGroup.Lancet1994;344:1383–9; 8.HeartProtectionStudyCollaborativeGroup.Lancet2002;360:7–22; 9.SeverPSetal.Lancet2003;361:1149–58; 10.ColhounHMetal.Lancet2004;364:685–96; 11.LaRosaJCetal.NEnglJMed2005;352(14
5、):1425-35; 12.WannerCetal.NEnglJMed2005;353(3):238-48;publishedaftertheCTTmeta-analysis 13.CholesterolTreatmentTrialists’(CTT)Collaborators.Lancet2005;366:1267-78.研究n(总计)n(糖尿病患者)危险降低(%)*未避免的事件%试验组对照组AFCAPS/TexCAPS16,60584713456PostCABG21,351635351NACARE34,1592823042575LI
6、PID49,0143963861981PROSPER55,804303320危险增加NAALLHAT-LLT610,3551,8551,78311894S74,444105974357HPS820,5362,9782,9852773ASCOT-LLA910,3051,2581,2741684CARDS102,8381,4281,41037634D111,2256196368NA荟萃分析1290,05618,6862377*主要终点,除外**严重冠脉事件。1.DownsJRetal.JAMA1998;279:1615–22;2.Hoogw
7、erfBJetal.Diabetes1999;48:1289–94;3.SacksFMetal.NEnglJMed1996;335:1001–9;4.TheLong–termInterventionwithPravastatininIschaemicDiseaseStudyGroup.NEnglJMed1998;339:1349–57;5.ShepherdJetal.Lancet2002;360:1623–30;6.ALLHATCollaborativeResearchGroup.JAMA2002;288:2998–3007;7.Sca
8、ndinavianSimvastatinSurvivalStudyGroup.Lancet1994;344:1383–9;8.HeartProtectionStudyCollaborativeGroup.L
