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1、联合检测CA199、CA242、CEA对胰腺癌诊断价值的meta分析颜海希郑静金霞霞沈波△317000临海浙江省台州医院检验科摘要目的评价联合检测血清CA199、CA242、CEA在胰腺癌诊断中的价值。方法采用计算机全而收集当前联合检测CA199、CA242、CEA对胰腺癌诊断性试验的文献。采用Meta・DiSc14.0、StatalO.O进行Meta分析。结果共纳入符合文献11篇。在合并分析中，化学发光法联合检测的灵敏度(SE)、特异度(SP)、SROC曲线下面积(AUC)分别为0.90(0.85〜0.93)、0.78(0.75〜0.8
2、3)、0.9513。单独检测CA199的SE、SP、AUC分别为0.80(0.75〜0.84)、0.81(0.76〜0.85)、0.8824。联合和单独两种检测方式的诊断效能比较差异冇统计学意义(Z=2.999,P=0.0027)o蛋白芯片法，联合检测的SE、SP、AUC、分别为0.84(0.80〜0.88).0.87(0.82〜0.91)、0.9293o单独检测CA199的SE、SP、AUC分别为0.78(0.73〜0.82)、0.86(0.81〜0.90)、0.8823、。联合和单独两种检测方式的诊断效能比较差异无统计学意义(Z=1.
3、141,P=0.157)o结论在胰腺癌的临床辅助诊断中，与单独检测CA199比较，联合检测的判别能力较强，可捉高诊断效能。关键词糖类抗原199(CA199)糖类抗原242(CA242)胰腺癌Meta分析△通讯作者：主任技师Tel:0576-85226374；E-mail:shenbkz@yahoo.com.cnCombinedDetectionofCA199,CA242andCEAintheDiagnosisofPancreaticCancer:AMetaAnalysisYanhaixi,zhengjing,jinxiaxia/shenb
4、o,ClinicalLaboratory.TaizhouHospitalofZhejiangProvince,Linhai,Zhejiang,China.E-mail:shenbk乙@yahoo.com.cn.)AbstractObjectiveThecurrentworkaimstoevaluatetheimportanceofcombineddetectionofthetumormarkersCA199>CA242andCEAinthediagnosisofPancreaticcanceroMethodsAcomputerizedli
5、teraturesearchwascarriedoutinthedatabasestocollectarticlesregardingthediagnosticvalueofcombineddetectionofthecancermarkersCA199>CA242andCEA。MetaDiScl4.0andStatalO.Osoftwarewereusedtoconductthemeta-analysisoResultsAtotalof11literatureswereobtainedinthecurrentstudywiththeun
6、ifiedinclusionandexclusioncriteria□Bychemiluminescenceimmunoassay,theresultsshowedthatthesensitivity(SE)，specificity(SP),areaundercurveofSROCcurve(AUC)ofthetumormarkersCA242,CA199,andCEAwere0.90(0.85-0.930.78(0.75-0.83)>0.9513,respectively,inthediagnosisofPancreaticcancer
7、。Incontrast,theindicesofSE，SP,AUCofthemarkerCAI99thatwasdetectedalonewere0.80(0.75-0.84)、0.81(0.76-0.85)、0.8824,respectivelyoTheresultoftheZtesthasproventhatsignificantdifferencesexistbetweenthetwomethodsindiagnosingPancreaticcancer(Z=2.999,P=0.0027)。Byproteinchipsystemfo
8、rmulti-tumormarkersdetection,theindicesofSE,SP,AUCofthetumormarkersCA242,CAI9-9,andCEAwere0.84(0
