资源描述:
《胰腺癌手术后靶区勾画RTOG共识.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、CONSENSUSPANELCONTOURINGCONSENSUSPANELCONTOURINGATLASFORTHEDELINEATIONOFTHECLINICALTARGETVOLUMEINTHECLINICALTARGETVOLUMEINTHEPOSTOPERATIVETREATMENTOFPANCREATICCANCERCollaborators•RossAAbramsMDRossA.Abrams,M.D.1,WilliamFRegineMDWilliamF.Regine,M.D.2,KarynA.Goodman,M.D
2、.3,LauraA.Dawson,MDM.D.4,EdgarBenEdgarBen-JosefMDJosef,M.D.5,KarinHaustermans,M.D.6,WalterR.Bosch,D.Sc.7,JuliusTurian,PhDPh.D11RushUniversityMedicalCollege,Chicago,IL;2UniversityofMarylandSchoolofMedicine,Baltimore,MD;MarylandSchoolofMedicine,Baltimore,MD;3MemorialSl
3、oanMemorialSloan-KetteringCancerCenter,NewYork,NY;4PrincessMargaretHospital,UniversityofToronto,Toronto,ON;5UniversityofMichiganMedicalSchool,AnnArbor,MI;6UniversityHospitalLLBLeuven,Leuven,Bellgiium;7Image-GiddThGuidedTherapyQACtQACenter(ITC),WashingtonUniversity,St
4、.Louis,MOBackground•Radiotherapy(RT)qualityassuranceisessentialtovalidttlidatetreatmentffitefficacy•RTfieldswereprospectivelyreviewedintheRTOG97-04studydemonstratingthat48%oftreatmentplansdidnotstudydemonstratingthat48%oftreatmentplansdidnotmeetprotocolrequirements.•
5、Basedon“ppperprotocol”versus“notppperprotocol”radiationdelivery,thefrequencyofgrade3/4toxicitydidnotvarysignificantlyonthe5-FUarmbutdidshowatdftrendofltiilesstoxicittftyforpatiittentsonthhegemciittbabiinearm.•Survivalwassignificantlyincreasedforpatientstreatedperprot
6、ocol(p=0019)perprotocol(p=0.019).Background•InRTOG0848,,pprosppectiveradiationqqualityycontrolisrequired•Centralreviewwillbeperformedpriortotreatmentdelivery•CT-basedplanningisrequired•Either3Dconformal(3DCRT)orintensityEither3Dconformal(3DCRT)orintensity-modulatedra
7、diotherapy(IMRT)planning•Thenormaltissuesmustbedelineatedandaclinicaltargetvolume(CTV)illbdfi(CTV)willbedefinedBackground•Tooesueensuretheeadequacyoadequacyoftheposepost-opeopearativeCTVaadondtodevelopstandardizedcontouringguidelinesforRTOG0848,aconsensuscommitteeofs
8、ixradiationoncologists,wihithexpertiiiseingastroiintestilRTdinalRT,devellopeddastepwisecontouringapproachbasedonidentifiableregions