低分子右旋糖酐联合速尿持续静脉滴注治疗小儿肾病综合征水肿50例.pdf

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1、·临床医药·中l虱茜2015年6月5日第24卷第11期ClinicalMedicineChinaPharmaceuticalsVo1．24，No．11，June5，2015低分子右旋糖酐联合速尿持续静脉滴注治疗4,JL肾病综合征水肿50例陆日舰(广西壮族自治区田阳县人民医院，广西百色533699)摘要：目的探讨低分子右旋糖酐联用速尿持续静脉滴注治疗小儿肾病综合征水肿的效果。方法将收治的小儿肾病综合征水肿患儿100例按随机数字表法分成对照组和观察组，各5O例。在常规治疗基础上，对照组患儿给予速尿静脉注射；观察组患儿使用低分子右旋糖酐联合速尿静脉滴注。结果观察组总有效率

2、为100．00％，明显优于对照组的70．00％(P<0．05)；观察组水肿消退时间(15．8±4．1)h、血清白蛋白升高时间(7．74-1．2)d、多尿时间(3．44-1．2)h，对照组分别为(28．34-12．1)h，(12．54-1．3)d，(14．1±2．5)h，观察组较对照组显著缩短(P<0．05)；观察组尿蛋白和血清胆固醇较对照组均显著降低，而观察组血清白蛋白水平较对照组显著升高(P<0．05)；观察组水肿复发率为6．00％，明显低于对照组的42．00％(P<0．05)。结论低分子右旋糖酐联用速尿持续静脉滴注治疗小儿肾病综合征水肿，效果突出，不良反应少，值

3、得推广。关键词：低分子右旋糖酐；速尿；小儿；肾病综合征；水肿中图分类号：R969．4；R973．5文献标识码：A文章编号：1006—4931(2015)11—0074—02ClinicalEfectofLowMolecularDextranCombinedwithContinuousIntravenousDripofFurosemideforTreatingNephroticSyndromeEdemainChildrenLuRijianrTianyangCountyPeople’sHospital，Tianyang,Guangxi，China533699)Abstr

4、act：ObjectiveToinvestigatetheeffectoflowmoleculardextrancombinedwithcontinuousintravenousdripoffurosemidefortreatingnephrotiesyndromeedemainchildren．Methods100childrenpatientswithnephroticsyndromeedemainourhospitalweredi—videdintothecontrolgroupandtheobservationgroupaccordingtotherando

5、mnumbertablemethod，50casesineachgroupOnthebasisofconventionaltreatment，thecontrolgroupwas舀venfurosemidebyintravenousinjection；theobservationgroupwasgivenlowmoleculardextranplusfurosemidebyintravenousdrip．ResultsThetotaleffectiverateaftertreatmentintheobservationgroupwas100％．whichwasobv

6、iouslyhigherthan70％inthecontrolgroup．thedifferencewasstatisticallysignificant(P<0．05)；theedemasubsidingtimewas(15．8±4．1)hintheobservationgroup，theserumalbuminincreasetimewas(7．7±1．2)dandthepolyuriatimewas(3．44-1．2)h，whichweresignificantlyshorterthan(28．34-12．1)h，(12．54-1．3)dand(14．1±2．

7、5)inthecontrolgroupre—spectively，thedifferenceswerestatisticallysignificant(P<0．05)．Theurineproteinandserumcholesterollevelsintheobservationgroupweresignificantlydecreasedcomparedwiththoseinthecontrolgroup，whilethelevelofserumalbuminintheobservationgroupwassignificantlyincreasedcompa