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时间:2020-04-17
《不同剂量顺式阿曲库铵对全麻诱导期老年患者肌松效应的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、!坦旦塑塑Clign0Yol_20l.87.不同剂量顺式阿曲库铵对全麻诱导期老年患者肌松效应的影响张在旺,蔡增华,杨小民,王金保[摘要]目的探讨全麻诱导期老年患者单次静脉注射不同剂量顺式阿曲库铵的肌松效应。方法选择美国麻醉医师协会(ASA)病情分级I一Ⅱ级择期手术的9O例,随机分为3组,每组30例。I组、Ⅱ组、Ⅲ组分别予顺式阿曲库铵0.1、0.15、0.2mg/kg静脉注射,待4个成串刺激(TOF)的第1个肌颤搐(T1)为0时行气管插管,并对插管条件进行评级。观察阻滞起效时间、TOF无反应期、阻滞维持时间、肌松恢复指数及体内作用时间。结果3
2、组T1最大阻滞程度及气管插管条件优良率比较差异无统计学意义(P>0.05),肌松起效时间组间比较差异有统计学意义(P<0.05),TOF无反应期、阻滞维持时间、肌松恢复指数、体内作用时间,组间比较差异均无统计学意义(P>0.05)。结论老年患者全麻诱导期静脉注射不同剂量的顺式阿曲库铵,无组胺释放作用,对血流动力学无影响,随着剂量增大,起效时间明显缩短,气管插管条件均满意,但肌松恢复时间与剂量、年龄无关。[关键词]阿曲库铵;老年人;麻醉,全身;肌松弛;神经肌肉阻滞[中国图书资料分类号]R982[文献标志码]A[文章编号]1002—3429(2
3、013)05—0087—04[DoI]10.3969/j.issn.1002.3429.2013.05.034NeuromuscularBlockingEffectsbyDifferentDosesofCisatracuriuminElderlyPatientsunderGeneralAnesthesiaduringInduetionPeriodZHANGZai—wang,CAIZeng—hua,YANGXiao—min,WANGJin—bao(DepartmentofAnesthesia,BethuneInternationalPeace
4、Hos—pita[PLA。Shijiazhuang05131382,China)[Abstract]ObjectiveToexploreneuromuscularblockingeffectsbydifferentdosesofCisatracuriumwithsingletimeforelderlypatientsundergeneralanesthesiaduringinductionperiod.MethodsAtotalof90patientsforselectiveoperationwithI一ⅡbyAmericanSociety
5、ofAnes【hesiologists(ASA)classificationwererandomlydividedintothreegroups(=30ineachgroup).Pa-tientsinI.ⅡandⅢgroupsreceivedintravenousbolusof0.1.0.15and0.2mg/kgcisatracuriumrespectively.Trachealcannulawasperformedwhenthefirstmyopalmus(T1)ofTOF—WatchSXwaszero,andintubatedcond
6、itionwasclassified.Theonsettime,TOF—WatchSXnonresponseperiod,durationofaction,recoveryindexesandinternalactiontimewererecorded.ResultsTherewerenotsignificantdifferencesinmaximuminhibitiondegreeandgoodrateoftrachealcannulainthreegroups(P>0.05),butthedifferencesofonsettimesi
7、nthethreegroupsweresignificantlydifferent(P<0.05).ThedifferencesinTOF-WatchSXnoreactionperiod,recoveryindexofgeriatricsandinternalactiontimewerenotstatisticallysignificantinthreegroups(P>0.05).ConclusionIntravenousinjectionofdifferentdosesofcisatracuriumforelderlypatientsw
8、ithgeneralanesthesiaduringinductionperiodmaynotcauseanydifferentchangeseitherinhistaminer
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