透明细胞性肾细胞癌和肾嫌色细胞癌的临床病理及免疫表型比较

《透明细胞性肾细胞癌和肾嫌色细胞癌的临床病理及免疫表型比较》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、6JournalofxiananUniversity(MedicalSciences)Mar．2010Vo1．12No．1透明细胞性肾细胞癌和肾嫌色细胞癌的临床病理及免疫表型比较胡玉林，吴海燕，曹慧秋，谢志彬，陈灿斌(郴州市第一人民医院病理科，湖南郴州423000)摘要：目的探讨透明细胞性肾细胞癌和肾嫌色细胞癌的临床病理学特征、诊断和鉴别诊断。方法对手术切除的57例肾透明细胞癌和22例。肾嫌色细胞癌进行临床特点、肉眼观、光镜和免疫组织化学染色。结果透明细胞性肾细胞癌多有血尿或肾区疼痛临床症状，巨检切面呈多彩状多伴出血、坏死及囊变；嫌色细胞癌临床上

2、大多无症状，巨检切面呈淡棕色，出血、坏死罕见。镜下透明细胞性肾细胞癌胞浆透明或嗜酸性；嫌色细胞癌胞膜厚似植物状、部分胞质嗜酸性可见明显核周空晕。免疫组化染色57例透明细胞性肾细胞癌E—cadherin全阴性表达，Vimentin全阳性表达，而22例嫌色细胞癌两者的表达正好相反，有显著性差异(P

3、7．11文章标识码：A文章编号：1673—498x{2olo)ol—ooo6—03doi：10．3969／j．issn．1673—498x．2010．01．002Clearcellrenalcellcarcinomaandchromophoberenalcellcarcinoma：acomparativestudyofclinicopathologicalandimmunophenotypeHUYulin，WUHaiyan，CAOHuiqiu，etal(TheFirstPeople’SHospitalofChenzhou，Chenzhou，Hun

4、an423000，China)Abstract：ObjectiveTostudytheclinicopathologicalfeatures。diagnosisanddiferentialdiagnosisofClearcellrenalcellcarcinoma(CCRCC)andChromophoberenalcelcarcinoma(CRCC)．MethodsFisevencasesofCCRCCand22casesofCRCCwereobservedwithclinicalcharacteristics，grossappearance，m

5、icroscopic，aswellasdetectedbyimmunohistochemicalstains．ResultsCCRCChastheclinicalsymptomofhematuriaandrenalpainandhascolorcrosssection，mostofthemfollowingwithhemorrhage，necrosisandcysticchange．whilemostofpatientsofchromophobecellcarcinomahasclinicallyasymptomaticandpalebrowni

6、ngrossappearance，rarelyhemorrhageandnecrosis．Histologicalexaminationshowedclearcellrenalcellcarcinomahasclearoreosinophiliccytoplasm；chromophobecellcarcinomaofthemembranethicklikeplant—cel。someofeosinophiliccytoplasmperinuclearspacehalocanbeseenclearly．Throughimmunohistochemi

7、ealstainswefound57casesofclearcellrenalcellcarcinomaE—cadherinexpressioninthewholenegative，Vimentinpositiveexpressionofthewhole，while22casesofchromophobecellcarcinomahasopposiflyexpression。theyweresignificantlydiferentbythesta—tisticalanalysis(P<0．O1)．ConclusionAlthoughclearc

8、elrenalcelcarcinomaandchmmophobecellcarcino—mahavesomecrossinmorphol