同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究.pdf

《同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、852JBengbuMedColl，July2014，Vo1．39，No．7[文章编号]1000-2200(2014)07-0852-03·临床医学·同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究孙卫华，张晓梅，李晓丽，时照明。裴晓艳。吴道爱[摘要]目的：探讨血浆同型半胱氨酸(Hcy)和C反应蛋白(CRP)与2型糖尿病大血管病变的关系。方法：免疫比浊法检测正常对照组(30名)、单纯糖尿病组(32例)及糖尿病大血管病变组(31例)血浆Hcy和CRP水平，观察其水平变化与糖尿病大血管病变的关系。结果：糖尿病大m管病变组和单纯糖尿病组血浆Hcy和CRP均明显

2、高于正常对照组(P<0．01)，单纯糖尿病组Hcy和CRP均显著低于糖尿病大血管病变组(P<0．01)；logistic回归分析显示收缩压、舒张压、糖化血红蛋白、三酰甘油、总胆固醇、高密度脂蛋白、Hcy和CRP均与动脉粥样硬化的发生相关。结论：2型糖尿病大血管病变患者血浆Hcy和CRP水平明显升高，消除动脉粥样硬化的危险因素如减轻体质量、控制血糖、纠正脂代谢紊乱、增强胰岛素敏感性、降血压等综合治疗可预防和延缓动脉粥样硬化的发生。[关键词]糖尿病性血管病；同型半胱氨酸；C反应蛋白；大血管病变[中国图书资料分类法分类号]R587．2【文献标志码]ATherelati

3、onshipbetweenthelevelsofhomocysteineandC-reactiveproteinandmacroangiopathyintype2diabetesmellitusSUNWei—hua，ZHANGXiao—mei，LIXiao—li，SHIZhao—ming，PEIXiao—yan，WUDao—ai(DepartmengtofEndocrinology，TheFirstAffiliatedHospitalofBengbuMedicalCollege，BengbuAnhui233004，China)[Abstract]Objectiv

4、e：Toinvestigatetherelationshipbetweenthelevelsofhomocysteine(Hcy)andC—reactiveprotein(CRP)andmacroangiopathyintype2diabetesmellitus．Methods：ThelevelsofplasmaHcyandCRPincontrolgroup(30cases)，simplediabetesmellitusgroup(32cases)anddiabeticmacroangiopathygroup(31cases)weredetectedusingi

5、mmunoturbidimetry．TherelationshipbetweenthelevelsofHcyandCRPanddiabeticmacroangiopathywasanalyzed．Results：ThelevelsofplasmaHcyandCRPinsimplediabetesmellitusanddiabeticmacroangiopathygroupweresignificantlyhigherthanthoseincontrolgroup(P<0．01)，thelevelsofplasmaHeyandCRPinsimplediabetes

6、meliitusgroupweresignificantlylowerthanthoseinanddiabeticmacroangiopathygroup(P<0．01)．Logisticregressionanalysisshowedthatthelevelsofsystolicbloodpressure，diastolicbloodpressure，HbA1C，triglyceride，totalcholesterol，hi．ghdensitylipoprotein，HcyandCRPwerecorrelatedtoartherosclerosis．Conc

7、lusions：ThelevelsofplasmaHcyandCRPintype2diabeticpatientswithmacroangiopathyincreasedsignificantly．Thetreatmentwithlosingbodymass，controllingbloodglucose，correctinglipidmetabolismdisorder，increasinginsulinsensitivityreducingbloodpressurecanpreventanddelaytheoccurrenceofartheroscleros

8、is．[Keywords