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时间:2020-04-25
《妊娠期肝内胆汁淤积症血清甘胆酸水平对围生儿及孕妇影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·临床研究·中国医药导报2014年3月第11卷第9期妊娠期肝内胆汁淤积症血清甘胆酸水平对围生儿及孕妇影响巩海亮河北省邯郸明仁医院妇产科,河北邯郸056006【摘要】目的观察妊娠期肝内胆汁淤积症(ICP)孕妇及胎儿结局,分析影响因素。方法回顾性分析2009年3月~2011年6月河北省邯郸明仁医院ICP孕妇130例为观察组,选择同期无ICP孕妇150例为对照组,检测并比较两组孕妇终止妊娠前血清甘胆酸水平。观察并比较两组产妇产后出血情况、新生儿分娩方式以及产后新生儿窘迫、新生儿窒息等胎儿预后情况。结果观察组血清甘胆酸水平[(1872.5~837.5)p~g/d
2、L】明显高于对照组【(137.6±79.3)txg/dL].差异有高度统计学意义(t=4.27,P<0.01)。观察组胎儿窘迫、新生儿窒息、早产发生率(44.6%、l8.5%、20.8%)均高于对照组(15.3%、6.0%、12.7%),差异均有统计学意义(x=16.673、6.715、4.146;P=0.002、0.001、0.015);观察组产妇分娩时大出血(≥400mL)、胎死宫内发生率(22.3%、3.8%)与对照组(12.0%、1_3%)相比较,差异均无统计学意义(x2=1.179、3.436;P=0.053、0.051)。随着血清甘胆酸水平升
3、高,胎儿窘迫、胎儿窒息、早产发生率升高。结论ICP对孕妇及胎儿均存在不良影响,对新生儿影响更大,且随着孕妇血清甘胆酸水平升高,新生儿预后愈差。临床上,对ICP患者应加强监测,及早采取干预措施。[关键词】胆法淤积症;新生儿预后;产后出血【中图分类号】R714.25【文献标识码]A【文章编号】1673—7210(2014)03(c)一0074—03EfectsofserumbileacidlevelonpregnantwomenwithintrahepaticcholestasisofpregnancyandtheirfetusesGONGHailiangD
4、epartmentofGynaecologyandObstetrics,MingrenHospitalofHandanCity,HebeiProvince,Handan056006,China【Abstract1ObjectiveToexploretheeffectsandinfluencefactorsofserumbileacidlevelofpregnantwomenwithin·trahepaticcholestasisofpregnancyfICP1andtheoutcomeoftheirfetuses.Methods130gravidaswi
5、thICPfromMarch2009toJune2011inMingrenHospitalofHandanCitywereselectedasobservationgroup,andtheother150casesofgravidaswhowithoutICPinthesameperiodwerechosenascontrolgroup.Theamountofpostpartumhemorrhageandtheserumbileacidvaluesbeforedeliveryweredetectedandcompared,andtherateoffeta
6、ldistress,neonatalasphyxia,prematuredeliveryoftwogroupswereobservedandcompared.ResultsThelevelofserumbileacidintheobservationgroup【(1872.5+837.5)txg/dL]wasobviouslyhigherthanthatinthecontrolgroup[(137.6~79.3)~g/dL],thedifferencewasstatisticallysignificantft=4.27,P<0.O1).Theincide
7、nceoffetaldistress,neonatalasphyxiaandprematuredeliv—cryintheobservationgroup(44.6%,18.5%,20.8%)wereobviouslyhigherthanthoseinthecontrolgroup(15_3%,6.0%,12.7%),thedifferenceswerestatisticallysignificant(X=16.673,6.715,4.146;P=0.002,0.001,0.015);theincidenceofpostpartumhemorrhage(
8、>/400mE)andstillbornfoetusininobservatio
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