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1、07细胞因子及其受体HistoryfortheresearchofthecytokinesIn1957,Interferon(IFN)wasfoundIn1969,termedlymphokineIn1974,denominatedcytokinecytokinology;internationalcytokinesociety《Cytokine》CompaniesfordevelopingcytokinesinmanycountriesCytockinesarelow-molecular-weightregulatoryproteinsorg
2、lycoproteinssecretedbywhitebloodcellsandvariouscells(vascularendothelialcell,epidermiccellandfibroblast)inbodyinresponsetoanumberofstimuli.CytokineBiologicaleffects:Regulationandtransferoftheinformationbetweentheimmunecells;Mediationandregulationoftheimmuneresponseandinflammation;R
3、elationshipwiththewoundhealing,theregenerationanddifferentiationofthehemopoieticstemcells-S-S--S-S--S-S-CCCCC1C3C2C1C3C2C1C3C2C1C3C2G蛋白cytokinereceptorsBiologicaleffectsofthecytokinesAnti-infectionandantitumorImmuneregulationapoptosisStimulatingtheproliferationanddifferentiationofh
4、emopoieticstemcellsPromotethegrowthanddifferentiationofvariouscellsParticipationandregulationoftheinflammatoryresponsesCytokineabnormalitiesinthepathogenesisincertaindiseasesParticipationofthenever--endocrine-immunitynet细胞因子的主要生物学效应抗感染和抗肿瘤作用免疫调节作用参与细胞凋亡刺激造血细胞增埴分化促进各种细胞的生长和分化参与和调节炎症
5、反应细胞异常可导致疾病的发生参与神经-内分泌-免疫网络参与免疫应答与免疫调节免疫应答识别(感应)阶段IFN刺激APCMHC-II的表达IL-1辅助T细胞活化IL-10抑制抗原递呈免疫应答细胞扩增阶段IL-2、IL-4、IL-5、IL-6等促进T、B细胞的增殖与分化TGF-b抑制淋巴细胞增殖参与神经-内分泌-免疫网络细胞因子对神经内分泌:IL-1、IL-6、TNF等直接参与神经系统的正常发育和损伤修复IL-1、TNF、IFN-g、PAF等诱导垂体释放ACTH,进而促进肾上腺皮质激素的释放应激时儿茶酚氨和糖皮质类固醇分泌增多,进而抑制IL-1、TNF的合成。在免
6、疫应答过程中,免疫细胞之间通过细胞因子相互刺激、彼此约束,对免疫应答进行调节,维持免疫系统的稳态平衡。1.白细胞介素(interleukin,IL)2.集落刺激因子(colonystimulatingfactor,CSF).3.干扰素(interferon,IFN)4.肿瘤坏死因子(tumornecrosisfactor,TNF)5.趋化因子(chemokine)6.生长因子(growthfactor,GF)细胞因子的种类Interleukin,ILinterleukinsaresecretedbysomeleukocytesandactuponotherl
7、eukocytes,IL-1~IL-23havebeenidentified.Colonystimulatingfactor,CSFThecytokinesthatstimulatehemopoieticcellstoformcellcolony,ParticipatehemopoieticfunctionarecalledCSF,forexampleGM-CSF,G-CSF,M-CSF,Epo,Tpo,GM-CSF具有干细胞集落刺激活性的细胞因子主要产生细胞作用SCF纤维母细胞,肝细胞,内皮细胞,上皮细胞,基质细胞所有类型的造血干细胞,黑色素细胞,肥大细胞
8、IL-3T细胞中性粒细胞,单核细胞,红细胞,嗜碱性粒