糖尿病肾病肾功能不全期中医证候学研究

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1、砧京中警蕖大萼BEIJINGUNIVERSITYOFCHINESEMEDICINE博士研究生学位论文题目：糖尿病肾病肾功能不全期中医证候学研究专业：中医内科学研究方向：糖尿病及其并发症的临床研究博士生：牟新导师：赵进喜教授=Oo六年六月中文摘要：{．典型相关结果提示形体肥胖之人，其证候类型多偏于痰湿。并且验证了导师赵进喜教授提出的糖尿病肾病中晚期患者普遍存在浊毒内停、气血损伤病机，治疗应重视益气养血、和胃泄浊解毒治法，泄浊毒、护胃气即所以保肾元的治疗思路。再者，认为内热伤阴是糖尿病的基本病机特点，贯穿于糖尿病发生发展的全过程，而血糖控制差的病人其内热的表现会更加明显。提示

2、这三项实验室指标可以做为临床辨证的依据。4．采用如聚类分析、探索性因子分析、典型相关分析等常见的降维统计学方法进行证候学研究具有一定的意义。本次研究在综合了多种方法后，认为跨学科研究是证候学研究的必由之路。主题词：方法学；数据挖掘；四诊信息；糖尿病肾病；证候学研究；糖尿病肾病‘肾功能不全期中医证候学研究ABSTRACTObjectiveInordertodiscusstheTCMsyndromepatternofdiabeticnephropathyrenalfailure，andtherelativityofdifferentTCMsyndromewiththesex，

3、ageandlaboratoryindices．ThisworkismeaningfullytoopenoutthecharacteroftheTCMsyndrome．MethodsThisresearchispartcontentofthefifteennationalscienceandtechnologytacklekeyproblem--theoptimizeprojectresearchofdiabeticnephropathyrenalfailurepreventionandcure．11leresearchproceedsthequestionaryofdi

4、abeticnephropathyestablishedaccordingtotaskgroup，collectingtheDiabeticNephropathysufferercamefromDozhimenHospitalofPel(ingChineseM胡icineUniversityetc．Includingcommonlyinstances，fourdiagnosticmethodsinformationofTCMandcorrelativelaboratoryindices．Lockupthedata-baseaftercheckingfiguresandas

5、snl'ancewithoutanyeTroratlast．Adoptthecompletecaseindataproceedstatisticsanalysis．AdoptionclusteringanalysisandfactoranalysistoanalysisandSumupthedistributingofTCMsyndrome；AdoptioncanonicalcorrelationanalysistoresearchandanalysistherelativityofthelaboratoryindiceswithdifferentTCMsyndrome,

6、andestablishsthegenerallyaccepted，scientificlaboratoryindicesrelatedTCMsyndrome．ResultsWediscoversthatthesuffereraremostlybelongtodeficiencyofQianddeficiencyofYin，phlegmanddampness，dampnessandturbid，stagnationofbloodstasisinrepayperiodofdiabeticnephropathyrenalfailure，deficiencyofYang，phl

7、egmanddampness，stagnationofbloodstasisaremostlyinloserepayperiodofdiabeticnephropathyrenalfailure．Thisresearchdiscoversthat186casesinrepayperiodofdiabeticnephropathyrenalfailurearedeficiencysyndromeaccompaniedwithexcesssyndrome，occupying95．3％；and66casessuffererinlos