icu脓毒症患者t淋巴细胞亚群、调节性t细胞检测的临床意义

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1、授予单位代码10089学号或申请号20153550中国图书分类号R631+.3HebeiMedicalUniversity硕士学位论文专业学位ICU脓毒症患者T淋巴细胞亚群、调节性T细胞检测的临床意义研究生：杜蕊导师：杨秀芬教授专业：急诊医学二级学院：河北医科大学第一医院2018年3月目录中文摘要············································································································1英文摘要·········

2、···································································································3英文缩写············································································································5研究论文ICU脓毒症患者T淋巴细胞亚群、Treg细胞检测的临床意义前言·······················

3、·····················································································7材料与方法······························································································9结果···················································································

4、······················11附图··········································································································14附表··········································································································16讨论·························

5、·················································································19结论··········································································································22参考文献··········································································

6、························22综述调节性T淋巴细胞亚群与脓毒症的研究进展·································26致谢············································································································34个人简历·········································································

7、································35中文摘要ICU脓毒症患者T淋巴细胞亚群、调节性T细胞检测的临床意义摘要目的：近年来研究发现，免疫紊乱在脓毒症发病的发生发展中起重要作用。现有的研究证实，在脓毒症发病发展过程中，伴随着T淋巴细胞亚群的变化，且与预后相关。随着对脓毒症发病机制研究的深入，调节性T淋巴细胞在疾病发展中所起的作用越来越被重视。但大多数研究多集中在动物实验上，临床上对调节性T淋巴细胞的研究尚不多。同时关于T淋巴细胞亚群与Treg细胞(调节性T淋巴细胞)的研究鲜有报道，因此，本研究旨在探讨T淋巴细胞

8、亚群与调节性T淋巴细胞水平在脓毒症疾病发展过程中的变化，进一步阐明在脓毒症发病过程中的免疫机制，为评价脓毒症病情程度及预后开辟新的临床途径。方法：选取2017年5月到2017年11月入住重症监护室(ICU)