血清pla2r抗体及thsd7a抗体检测在特发性膜性肾病中的临床意义

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1、授予单位代码10089学号或申请号20153335中国图书分类号R692.3HebeiMedicalUniversity硕士学位论文专业学位血清PLA2R抗体及THSD7A抗体检测在特发性膜性肾病中的临床意义研究生：张文贤导师：刘茂东副教授专业：内科学二级学院：第三医院2018年3月目录中文摘要··········································································································1英文摘要····································

2、······································································3英文缩写··········································································································5研究论文血清PLA2R抗体及THSD7A抗体检测在特发性膜性肾病中临床意义前言··········································································

3、································6材料与方法······························································································7结果········································································································10附图····················································

4、····················································11附表········································································································13讨论········································································································15结论·······················

5、·················································································18参考文献································································································18综述血清PLA2R抗体及THSD7A抗体在特发性膜性肾病诊治中的研究进展··········································································

6、····················21致谢················································································································29个人简历········································································································30中文摘要血清PLA2R抗体及THSD7A抗体检测在特发性膜性肾病中的临床意义摘要目的：近年来，

7、研究已证明PLA2R与THSD7A为IMN主要致病抗原，肾组织抗原的沉积及血清特异性抗体与疾病相关。肾穿刺活检为诊断金标准，但为有创性操作，不便动态观察,而血清学检测更简单易行。本实验旨在通过检测IMN患者血清PLA2R及THSD7A抗体水平，来探讨二者对IMN诊断及病情评估的意义。方法：选取2016.09-2017.12在河北医科大学第三医院肾内科，行肾穿刺活检诊断特发性膜性肾病114例作为观察组，V-型狼疮性肾炎7例、IgA肾病16例作为对照组。采用E