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1、英文摘要ThecorrelationbetweenVasopressin,Urotensin—IIandHyponatremiainlivercirrhosiswithascitesABsTRACTHyponatremiaiswhensenlmsodiumiSlessthanorequaltO135mmol/L.HyponatrerIliaiscommonintheascitesoflivercirrhosis.CombiningthedomesticreportsofChina,theinciden
2、cerateoflivercirrhosisascitescomplicatedhyponatremiais50--60%,30%byaseriesofforeignreports.Thehyponatremiaoflivercirrhosisasciteshasnospecificclinicalmanifestation,anditssymptomshavesomethingtodowithcomplication,severityofhyponatremia,age,sex,ete.Hypona
3、tremiahastwocases,withoutsymptomsormanifestsitself,forexamplenausea,debility,disorientation,headache,lethargy,blurredvision,evenencephalopathyincludingmindconfusing,delire,epilepticattack,ere.Peopleoftenmisinterpretthese器hepaticcoma.Whenseu衄sodiumisless
4、thanorequalto15mmol/L,itsclinicalmanifestations(debility,headache,muscleconvulsion,apthy,lethargy,mentalsubnormality,delirium,convulsion,coma)areclear,andeven10wnatriumencephalopathyleadtocardiorespiratoryarrest.Whenlivercirrhosiscomplicatedacutelownatr
5、iumsyndrome(ALNS),itsclinicalmanifestationsareoftennausea,vomiting,debility,ere.Ands@veresubjectshavesymptomsofunorientation,blurredvision,coma,andperipheralcirculatoryfailure.Whensertlnl荚文摘要sodiumisIesst11a11orequaltO135mm01/Landosmoticpressureofplasma
6、ismorethan280mmol/L,itmayberegardedaspseudo—hyponatremia.ThereflsonflmayberelatedtOhyperglycemia,hyperlipemia,etc.Thegradingofhyponatremiaisthelighthyponatremiawhenserumsodiumis130~135mmol/L,themiddlehyponatremiawhenserBinsodium’is125-130mmoFLandtheseve
7、rehyponatremiawhenserumsodiumislessthanorequalto125mmol/L.Vasopressin(VP)canregulatetheconcentrationofufineinmedullsintemaofkidney,andincreasethepermeabilitytowaterincollectingduct.Inlivercirrhosis,thesecretionofVPisstimulatedbynon-osmolarity,forthechan
8、geofhemorrheology,includingthedecreaseofcentralhypovolemiaandtheincreaseofperipheralvascularresistanceandthedecreaseofeffectivebloodvolumeleadstOnon-osmolaritysecretionofVP.Althoughplasmaosmoticpressuredecreased,stimulationofnono