子宫内膜异位症与血管生成与增殖的相关性分析

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1、军医进修学院硕士学位论文ThestudyfortheInterrelationbe伽eenEndometriosis&An2iogenesisandProlif．eration·＆AnglogeneSlSand王，ronteratlOnAbstl曩ctobjective：ThepuIposeofmisstudyw勰toinVestigatet11eexpressi6nofmecorrelationf‘actorsofan百ogenesis，includillgV鹤cuIar印imelialgrow吐lfactor(vEGF)锄db邪ic矗broblaStgrow

2、吐l缸tor(bFGF)aIldⅡleexpressionofapr01if．emtiVem矾【er嵇-67oneutopicendometrium饵u-em)andectopicendometrium①c—em)ofendometriosis①Ms)oradenomyosis(Am)，觚dt0investigate廿leeXpressionofⅦGFiIlperitonealnuidpF)ofendome仃iosis．Mate订alsandmethods：1．Patientswereobta．med丘DmnleD印．ofGyn．&Obs．iIlmePLAGen

3、eralHo叩italunde日萨iIlgl印aroscopyandtotalVagiIlalhysterectomy舶mApriltoOctoberiIl2004．Therewere20c雏esfespectivelyin5groups，inchldingEu-em锄dEc-em铲oupsiIlEMsorAmandmeconnDlsofno吼alendometrium，derivedfbmtllepatientsunder90nesu玛icaloperationf．or廿1ecaSeofi11危rtilityoromerbenign鄹mecologicaldi

4、seaSes．TheeXpressionofVEGF锄dbFGFduringmenstrualcyclealldbcorrelationShipwi也本课题受国家自然科学基金重点课题。子富内膜异位症侵袭机理研究一瓷助6军医进修学院硕士学位论文Ⅺ·67were妣alysedbyimmlmohistochemicald砌stailling．11herewere47caseSi11n搪vEGFgroup，i11cluding16c勰嚣ofEu-锄觚d5ofEc-emofEMs，15Eu-emand12Ec一锄ofAJn，锄d16no瑚alcon缸Dls．nerewer

5、e44casesill‰bFGFg加up，includillg14c嬲esofEu-emofEMs，16Eu—emand14Ec-emofAm．andl4no咖aIcontrols．2．PFw丛obtained舶m60c鹪esofpatientsiIlmePLAGeneralHoSp蹦undergoingI印aroscopy筋mOctoberin2004t0ApriliIl2005．Therewere40c嬲esofEMs，iIlclud啦!3ofI一Ⅱstage锄d27ofⅢ-Ⅳstage，and20con缸D1s．TIlechaIlgeofVEGFconte

6、ntofPFw鹊mestigatedbyELISAm劬odsinme【o】con仃01saIldgr0唧sofdi虢rentstagesofEMs．SilIlultalleously，wealsostIldiedmee髓ctofⅦGFiIlPFon廿1epanlogenesisofl珀订s．Results：1．neeXpressionofⅦGF，髓-67a11dbFGFonEu-emofEMs：①VEGF：Thefe哪alessv撕ationofcyclic驴cial毋ofVEGFeXpressioniIl廿legIandular印ithelialcells(G

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