迟缓爱德华菌菌蜕疫苗的构建及动物免疫试验

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1、AdissertationSubmittedtoNanjingAgriculturalUniversityInpartialfulfillmentoftherequirementsforTheDegreeofDoctoroftheAgronomy(Hydrobiology)CompletedinJune2009指导下，独立进行研究工作包含任何其他个人或集体己的个人和集体，．均己在文中人承担。砷’年l玛t3日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，同意学校保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和

2、借阅。本人授权南京农业大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编学位论文。保密口，在——年解密后适用本授权书。本学位论文属于不保密口。(请在以上方框内打“√")学位论文作者(需亲笔)导师(需亲笔)签名：卅年6疑t岁日叼年易其6龟3．2外膜蛋白(OMP)··············································83．3运动性(Motility)··············································93．4III型分泌系统(Typ

3、eIIIsecretionsystem，TTSS)·····················93．5毒力基因(VirulenceGenes)····································-114病理和诊断········································-··············114．1概述··············-·········································1l4．2组织病理学·······································

4、·-·········124．3血液病理学和血清学··········································124．4免疫相关基因的表达···················-······················124．5分子诊断法··················································125防治·····························································136总结与展望·························

5、······························15第二章细菌菌蜕研究进展···············································171菌蜕形成的机制·······-········-··································172菌蜕的制备·······················································183菌蜕的应用··················-····································193．1

6、菌蜕疫苗····················································193．2菌蜕疫苗与细胞免疫·········································"213．3菌蜕疫苗与粘膜免疫·········································-224菌蜕作为抗原、核酸和药物的载体····································22{ⅡX1255呕～Ⅵ啦¨一●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●迟缓爱德华菌菌蜕疫苗的构建及

7、动物免疫试验4．1茵蜕作为抗原载体···········································"234．2菌蜕作为核酸载体············································284-3菌蜕作为药物载体···························-················295免疫佐剂········································-····-···········306展望·-····································

8、·······················31第