乳腺实性乳头状癌临床病理学特征_杨苗苗

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1、临床与实验病理学杂志JClinExpPathol2014May;30(5)·491·网络出版时间:2014－5－2013:28网络出版地址:http://www．cnki．net/kcms/doi/10．13315/j．cnki．cjcep．2014．05．005．html乳腺实性乳头状癌临床病理学特征1，21，31杨苗苗，翁海燕，孟刚摘要:目的探讨乳腺实性乳头状癌的临床病理学特征。方法收集9例乳腺实性乳头状癌，行HE及免疫组化染色，根据WHO(2012)乳腺肿瘤标准进行分类。结果9例乳腺实性乳头状癌中原位实性乳头状癌7例、浸润性实性乳头状癌2例。肿瘤细胞呈多结节状生长，结节呈圆形、类圆形，

2、边缘光滑，可见神经及脂肪组织内浸润。结节内瘤细胞常见假菊形团及细胞核围绕脉管轴心呈栅栏状排列，7例见较明显黏液产生。9例癌组织巢内细胞CK8、EＲ均弥漫阳性，巢周及巢内肌上皮SMA、p63、CD10均阴性。8例Syn阳性，3例CgA阳性。2例浸润性实性乳头状癌:浸润成分类似浸润性导管癌，但细胞形态类似原位癌，且免疫组化标记Syn阳性。结论乳腺实性乳头状癌呈结节状生长，可见结节浸润神经及脂肪组织内，癌巢周围肌上皮SMA、p63、CD10均阴性。乳腺实性乳头状癌可能是呈推挤性生长的浸润性癌。关键词:乳腺肿瘤;实性乳头状癌;病理学特征;免疫组织化学中图分类号:Ｒ737．9文献标志码:A文章编号:1

3、001－7399(2014)05－0491－04doi:10．13315/j．cnki．cjcep．2014．05．005Pathologicalcharacteristicsofsolidpapillarycarcinomasofthebreast1，21YANGMiao-miao，WENGHai-yan-1，3，MENGGang12(DepartmentofPathology，AnhuiMedicalUniversity，Hefei230032，China;DepartmentofPathology，AnhuiNo．2ProvincePeo-3ple’sHospital，Hefei230

4、041，China;DepartmentofPathology，AnhuiProvincialHospital，Hefei230001)Abstrast:PurposeToinvestigatetheclinicalmanifestation，morphologiccharacteristicsandimmunophenotypicfeaturesofsolidpa-pillarycarcinomas(SPC)ofbreast．MethodsAccordingtocriterionofWHO(2012)，9casesofSPCofbreastwereselectedandobservedwi

5、thhematoxylineosinstainingandimmunohistochemistry．Ｒesults9casesofSPCwerediagnosedincluding7casesofSPCinsituand2casesofinvasiveSPC．Microscopically，thesetumorsappearedasmultiplenodules．Nodulesdisplayedwell-definedpush-ingbordersandinvadedfattissueandnerve．Nuclearpalisadingaroundthestromalcoresandpseu

6、dorosetteformationaroundcapillaryvesselswerealsocommonfeatures．Extracellularmucinproductioncouldalsobepresentin7cases．AllcaseswerepositiveforEＲandCK8，negativeforSMA，p63，CD10．8caseswerepositiveforSyn．3caseswerepositiveforCgA．2caseswereassociatedwithinva-sivecarcinoma．Theinvasivecomponenthadaneuroend

7、ocrine-likepatternandwasmorphologicallysimilartotheadjacentSPC．Con-clusionSPCmaydisplaynodular，well-definedpushingborderandinvadefattissueandnerve．Theabsenceofmyoepithelialcellsattheperipheryofthetumoriscon