奥氮平合并劳拉西泮治疗广泛性焦虑疗效分析

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1、2013年12月中国民康医学Dec，2013第25卷上半月第23期MedicalJournalofChinesePeoplesHealthVol_25FHMNo．23【论著】奥氮平合并劳拉西泮治疗广泛性焦虑疗效分析赵勇，陈红玉，鲁晓波(湖北省随州市精神病医院，湖北随州441300)【摘要】目的：分析奥氮平合并劳拉西泮治疗广泛性焦虑的疗效和安全性。方法：随机将96例广泛性焦虑分为奥氮平合并劳拉西泮治疗组52例和单用劳拉西泮对照组44例。两组在性别、年龄和病程上均无显著性差异(P>0．05)。在治疗前和治疗第2、6周末采用汉密尔顿焦虑量表(HAMA)及副反应量表(TESS)评定

2、疗效及不良反应。结果：两组2、6周末的HAMA总分和因子分都有明显降低，随着疗程延长各降分更为明显。两组间比较，治疗组6周末HAMA总分和躯体焦虑因子分降分明显大于对照组(P<0．05)，显效率明显高于对照组P<0．05)。治疗组奥氮平以小剂量为主，劳拉西泮用量低于对照组(P<0．01)，不良反应则明显轻于对照组。结论：小剂量奥氮平合并劳拉西泮治疗广泛性焦虑具有增效及减轻药物不良反应的特点。【关键词】奥氮平；劳拉西泮；广泛性焦虑doi：10．3969／j．issn．1672-0369．2013．23．006中图分类号：R749．72文献标识码：B文章编号：1672—0369

3、(2013)23—0013—02CurativeefectanalysisofolanzapinecombinedwithlorazepamintreatmentofgeneralizedanxietydisorderZHA0Y0ng，CHENHong-yu，LIXiao_ho(Suizhoupsychiatrichospital，Hubei441300，China)【Abstract】Objective：Toanalyzeeficacyandsafetyofolanzapinecombinedwithlorazepamintreatmentofgeneralizedanx

4、ietydisorder．Methods：96patientswithgeneralizedanxietydisorderwererandomlydividedintoolanzapinecombinedwithlorazepamtreat—mentgroup(52cases)andcontrolgroup(44cases，treatedonlywithlorazepam)．Thetwogroupswerenotsignificantlydiferentingender，ageanddiseaseduration(P>0．05)．Beforeand2and6weeksaft

5、erthetreatment，Hamiltonanxietyscale(HAMA)andtreatmentemergentsymptomscale(TESS)wereusedtoassesstheeficacyandadversereactions．Results：2and6weeksafterthetreatment，theHAMAtotalscoresandfactorscoresofthetwogroupsweresignificantlyreduced，andthesituationwasmoreobviousasthecoursewasprolonged．Thed

6、ecreaseoftheHAMAtotalscoreandsomaticanxietyfactorscoreofolanzapinecombinedwithloraze—pamtreatmentgroupwashigherthanthatofcontrolgroup6weeksafterthetreatment，andthemarkedlyeffectiveratewasalsohigherthanthatofcontrolgroup(P<0．05)．Duetothattreatmentgroupusedasmalldoseolanzapineasthemaindrug，t

7、helorazepamdosewaslowerthanthatofthecontrolgroup(P<0．01)．Moreover，theadversereactionsweresignificantlylighterthanthatofcontrolgroup．Conclusions：Asmaldoseolanzapinecombinedwithlorazepaminthetreatmentofgeneralizedanxietydisorder．hastheadvan—ragesofhigheficiencya