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1、阿徳福韦酯与拉米夫定治疗慢性乙型肝炎对比分析［摘要］目的比较阿徳福韦酯(贺维力)与拉米夫定(贺普丁)治疗慢性活动性乙型肝炎的临床疗效，以提高有效率，减少耐药性。方法收集我院200X年12月〜2011年1月经消化内科应用上述两种药物系统治疗慢性活动性乙型肝炎患者150例，根据用药分为三组备5()例：分别为使用贺维力、贺普丁及两种药物合用。分别于治疗的12、24、36、52周观察HBV-DNA病毒复制情况及ALT阴转率，比较各组问患者的临床疗效。结果贺维力组连续治疗52周，各时期HBV-DNA转阴率分别
2、为32.0%、54.0%、62.0%、74.0%；贺普丁组分别为4&0%、52.0%、52.0%、66.0%；联合用药组分别为48.0%、54.0%、68.0%、78.0%0经过贺维力组连续治疗52周，备时期ALT转阴率分别为30.0%、44.0%、76.0%、70.0%；贺普丁组分别为60.0%、68.0%、80.0%、72.0%；联合用药组分别为62.0%、66.0%、74.0%、74.0%o结论治疗52周时，贺维力组HBV-DNA及AUT转阴率略好于贺普丁组，与联合用药组无明显茅异。［关键词］
3、贺维力；贺普丁；慢性活动性乙型肝炎［中图分类号］R512.6+2［文献标识码］B［文章编号］1673-9701(2011)33-46-02ComparativeStudyofAdefovirDipivoxilandLamivudineintheTreatmentofChronicHepatitisBQULichun1ZHAOHai2ZHAOHongran3LANLanl1.MRIRoom,DaqingOilFieldGeneralHospital,Daqing163001,China;2.Depar
4、tmentofRadiology,DaqingRanghuluRailwayHospital,Daqing163712,China;3.MedicalDeviceDivision,DaqingRanghuluRailwayHospital,Daqing163712,China［Abstract］ObjectiveTocomparethepowerofAdefovirdipivoxilandLamivudineinthetreatmentofchronicactivehepatitisBclinica
5、lefficacy,soastoimproveelTiciency.MethodsAllof150caseswerecollectedwhichweretreatedbytwodrugswementionedinourhospitalfromDesember2008toJanury2011.Allcasesinthreegroupsaccordingthetreatment:group1:AdefovirDipivoxil;group2:Lamivudine;Group3:twodrugscombi
6、nationused,50casesrespectively.inthetreatmentof12weeks,24weeks,36weeks,52weeksobservedHBV-DNAviralreplicationandALTnegativerate,comparingtheclinicalefficacybetweeneverytwogroups,andanalysistheresult.ResultsAfter52weekstreatment,ingroup1theHBV-DNAnegati
7、verateswere32.0%,54.0%,62.0%,74.0%;ingroup2:48.0%,52.0%,52.0%,66.0%;ingroup3:48.0%,54.0%,68.0%,78.0%.AftercontinuoustreatmentbyAdefovirDipivoxilfor52weeks,theALTnegativerateswere,1:30.0%,44.0%,76.0%,70.0%;group2:60.0%,68.0%,80.0%,72.0%;group3:62.0%,66.
8、0%,74.0%,74.0%.ConclusionAfter52weekstreatmentbythedrugofgroupl,thenegativeratioofHBV-DNAandALTslightlybetterthangroup2,withnosignificantdifferenceinthegroup3.［Keywords］Adefovirdipivoxil;Lamivudine;ChronicactivehepatitisB在我国病毒性肝炎发病率明显高于
