资源描述：
《31例胃小间质瘤临床特点及预后分析_》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、730中国肿瘤临床2013年第40卷第12期ChinJClinOncol2013,Vol.40,No.12www.cjco.cn31例胃小间质瘤临床特点及预后分析*黄振李原赵宏赵建军蔡建强摘要目的：探讨原发于胃的小间质瘤的临床病理特点和预后影响因素。方法：回顾性分析1999年3月～2012年3月期间在中国医学科学院肿瘤医院接受手术治疗并经病理证实的31例胃小间质瘤的临床资料，统计临床特点并分析影响其预后的因素。结果：31例患者中29例获得随访（随访率93.5%）。其中男性10例，女性21例，中位年龄58（37～81）岁。腹部不适和腹痛是最主要的首发症状（各10例，32.3%）。全组患者
2、均接受手术治疗，胃大部切除和胃壁局部切除各11例，腹腔镜下胃壁局部切除5例，胃镜下肿瘤剥离4例，术后无重大并发症。截止到随访终点，肿瘤复发2例，肝转移1例；因肿瘤进展死亡1例，因其他恶性肿瘤死亡1例。中位总生存时间（OS）预测值为130.4个月，中位无疾病进展时间（PFS）预测值为120.3个月。结论：胃小间质瘤总体预后较好；手术切除是主要治疗方式，可根据情况选取微创治疗方式；肿瘤坏死、出血和胃黏膜受累可能是预后不良因素。关键词胃肠道小间质瘤外科手术微创预后doi:10.3969/j.issn.1000-8179.2013.12.012Prognosticfactorsandclini
3、copathologicalcharacteristicsofsmallgastrointestinalstromaltumorofthestomach:Aretrospectivestudyof31casesZhenHUANG,YuanLI,HongZHAO,JianjunZHAO,JianqiangCAICorrespondenceto:JianqiangCAI;E-mail:caijianqiang188@sina.comDepartmentofAbdominalSurgery,CancerInstituteandHospital,ChineseAcademyofMedicalS
4、cienceandPekingUnionMedi-calCollege,Beijing100021,ChinaThisworkwassupportedbytheClinicalResearchSpecialFoundationoftheWuJiepingMedicalFoundation(No.320675012622)AbstractObjective:Thepresentstudyaimedtoanalyzetheclinicopathologicalcharacteristicsandprognosticfactorsofsmallgastrointestinalstromalt
5、umors(GISTs)ofthestomach.Methods:Atotalof31smallgastricGISTpatients,10malesand21females,withamedianageof58yearsold(37～81years),whounderwentsurgeryatanytimefrom1999to2012wereincludedinthisstudy.Theclinicalrecordsofthepatientswereanalyzedretrospectively.Results:Abdominaldiscomfortandpain(10cases,3
6、2.3%,respective-ly)werethetwomostcommoncomplaintsamongthepatients.Allpatientsreceivedsurgery,11receivedgastricwedgeresection,11re-ceivedsubtotalgastroectomy,5receivedlaparoscopicgastricwedgeresection,and4receivedendoscopicsubmucosaldissection.Nose-vereadversecomplicationwasobserved.Atotalof29pat
7、ients(93.5%)werefollowedup.Duringthefollow-up,2patientswerefoundtoexhibittumorrecurrence,and1patienthadlivermetastases.Onepatientdiedoftumorprogression,whileanotherdiedofanotherma-lignanttumor.Medianprogression-freesurvival(
