超声波联合低分子肝素钙治疗脑梗死的疗效及其血浆溶血磷脂酸水平的改变.pdf

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1、·378·JClinNeuro1，October2013，Vo1．26，No．5·学术交流·超声波联合低分子肝素钙治疗脑梗死的疗效及其血浆溶血磷脂酸水平的改变郝树森，高连生，康红霞，张丽英，李军，常宁，杨晓玲，綦航，刘皇哲【摘要】目的探讨体外超声波联合低分子肝素钙治疗脑梗死的疗效及其血浆溶血磷脂酸(LPA)水平的改变。方法110例脑梗死患者随机分为联合治疗组(n=60)和对照组(n=50)。两组患者均给予低分子肝素钙5000U皮下注射，每天2次；疏血通6ml加入生理盐水250ml静脉滴注，每天1次；连续14d。联合治疗组同时加用体外(头部)超声波治疗，每天2次，

2、连续14d。在治疗前及治疗后进行神经功能缺损程度评分(NDS)，以及用复合磷定法检测血浆LPA含量。根据患者治疗后NDS的改变评定疗效。结果两组治疗后的NDS和血浆LPA水平均比治疗前显著降低(P<0．05～0．01)，而联合治疗组治疗后的NDS和血浆LPA水平又均显著低于对照组(P<0．05—0．01)。联合治疗组的显效率(55％)和总有效率(91．6％)均明显高于对照组(36％，70％)(P<0．05—0．01)。结论超声波联合低分子肝素治疗脑梗死有显著的效果；其机制可能与联合治疗能抑制LPA的释放，降低血浆LPA水平有关。【关键词】脑梗死；超声波；低分子肝

3、素钙；溶血磷脂酸【中图分类号】R743．3【文献标识码】A【文章编号】1004—1648(2013)05-0378-03EfectsofultrasoundcombinedwithlowweightheparincalciumintreatingcerebralinfarctionandthechangeofplasmaleveloflysophospholipidsacidHAOShu—sen，GAOLian—sheng，KANGHong—xia，eta1．DepartmentofInternalMedicine，theEighthHospitalofSh~／

4、iazhuang，Shijiazhuang050081，ChinaAbstract：ObjectiveToexploretheeffectsofultrasoundcombinedwithlowweighthepafincalciumintreatingcerebralinfarctionandthechangeofplasmaleveloflys0phospholipidsacid(LPA)．MethodsOnehundredandtenpatientswithcerebralinfarctionwererandomlydividedintocombinedt

5、reatmentgroup(n=60)andcontrolgroup(n=50)．Thepatientsintwogroupsweregivenlowweightheparincalcium5000Usubcutaneously，twiceaday；Shuxuetong6ndinnormalsaline250mlintravenousdrip，onceaday；for14consecutivedays．Thecombinationgroupcombinedwithinvitro(head)ultrasonictreatmentatthesametime，towt

6、imesaday，for14consecutivedays．Beforeandaftertreatment，thepatientswerescoredfordegreeofneur~functiondefect(NDS)，anddetectedtoplasmaU)Alevelsusingcompositepralidoximemethod．Accordingthechangeofpatients’sNDSaftertreatment．thecurativeeffectswasevaluated．ResultsTheNDSandplasmaIAlevelsintw

7、ogroupsaftertreatmentweresignificantlylowerthanbeforetreatment(P<0．05—0．01)，andthoseincombinedtreatmentgroupaftertreatmentweresignificantlylowerthancontrolgroup(P<0．05—0．01)．Theeffictualrate(55％)andtotaleffectiverate(91．6％)incombinedtreatmentgroupweresignificantlyhigherthanthoseincon

8、trolgroup(36