幽门螺杆菌baba2和胃黏膜上皮leb抗原在不同血型中表达情况及与消化性溃疡的关系

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1、幽门螺杆菌babA2和胃黏膜上皮Leb抗原在不同血型中表达情况及与消化性溃疡的关系作者：邓淑娟,李兴华,方德宁,曾钗明【摘要】目的：研究不同血型(ABO)患者幽门螺杆菌(Helicobacterpylori,Hp)表达血型抗原结合黏附素(bloodgroupantigenbindingadhesion,babA2)和胃黏膜上皮表达Lewisb(Leb)情况,及两者与消化性溃疡的关系。方法：测定56例(25例胃炎,31例消化性溃疡)Hp阳性消化性溃疡及消化不良的患者血型,并进行内镜检查,取2块胃黏膜,一块进行Hp培养,采用PCR检测HpbabA2表达情况;另一块组织进行

2、组织病理学检查,并应用免疫组化测定胃黏膜上皮表达Leb情况。分别比较不同血型babA2、Leb表达情况与消化性溃疡的关系。结果：56例患者中,消化性溃疡组O型血所占比例高于胃炎组及正常人群(P均<0.0125),O型血患者胃黏膜Leb评分显著高于非O型血(P<0.005),消化性溃疡组Leb评分高于胃炎组(P<0.05)。Hp培养成功30例,有28例babA2阳性(7例消化性溃疡,21例胃炎),babA2阳性患者中,消化性溃疡组O型血比例高于非O型血(P<0.0125),消化性溃疡组与胃炎组O型血所占比例差异无统计学意义。结论：O型血可能是通过

3、高表达Leb及Hp的babA2增加了消化性溃疡的发生。【关键词】12幽门螺杆菌;血型抗原结合黏附素;Lewisb;消化性溃疡　　[Abstract]Objective:ToinvestigatethebabA2ofHelicobacterpylori(Hp)andhostgastricLewisb(Leb)antigenstatusindifferentABObloodgroup,anddeterminetherelationshipbetweenthepepticulcerwithit.Methods:DetectedABObloodgroupof56Hpposi

4、tivepatients(25withgastritis,31withpepticulcer)withpepticulcerandindigestion.Twogastricspecimensgotbyendoscopy.OnewasculturedanddeterminedforbabA2genotypebypolymerasechainreaction.GastricexpressionofLebobtainedfrompatientswiththeotheronesamplewasmeasuredimmunochemicallytodetermineintens

5、ity(range0-9).ExpressionofbabA2andLebindifferentbloodgroup,andtherelationshipwithpepticulcerwerecompared.Results:Among56patients,Otypebloodproportioninpepticulcerwashigherthantheproportionofgastritisgroupsandnormalgroups(P<0.0125),LebantigenscoreofOtypebloodwassignificantlyhigherth

6、annoObloodtype(P<0.005).Thirtygastricspecimenswereculturedsuccessfullyand28caseswerebabA2positivestrains(7withpepticulcer,21withgastritis),amongbabA2positivepatientswithpepticulcer,Otypebloodproportionwashigherthanno12Obloodtype(P<0.0125).Therewasnosignificantdifferencebetwee

7、npepticulcerandgastritis.Conclusion:ObloodtypeincreasedincidenceofpepticulcermaybethroughhighexpressionofLebandbloodgroupantigenbindingadhesionofHp.　　[Keywords]Helicobacterpylori;bloodgroupantigenbindingadhesion;Lewisb;pepticulcer　　消化性溃疡是临床常见病、多发病,O型血的人更容易患消化性溃疡[1-3]。ABO血型抗原除表达