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1、实用儿科临床杂志第22卷第22期2007年11月JApplClinPediatr,Vol.22No.22,Nov.2007·7071··论著·急性白血病儿童医院感染71例贾月萍,刘桂兰,张乐萍,陆爱东(北京大学人民医院儿科,北京100044)摘要:目的了解儿童白血病发生医院感染的临床特点,探讨其防治措施。方法回顾性分析133例急性白血病患儿发生医院感染的特点。总结医院感染与病程阶段、住院天数的关系及感染部位、感染率,并进行统计学处理。结果医院感染率为53.4%(71/133例)。其中急性淋巴细胞白血病与急性非淋巴细胞白血病例次感染率有显著性差异(P<0.0
2、5);住院第1～3次组医院感染例次高于其他组(Pa<0.05),住院天数为1～7d组医院感染例次低于其他组(Pa<0.05);复发与未复发组人均医院感染例次无显著性差异(P<0.05);败血症以革兰阴性杆菌为主,药敏结果显示普遍敏感的药物为阿米卡星、哌拉西林/他佐巴坦。结论急性白血病患儿医院感染发生率高,医院感染发生与白血病类型、病程阶段、住院天数有关;与预后无关,败血症以革兰阴性杆菌为主。实用儿科临床杂志,2007,22(22):1707-1708关键词:儿童;白血病;医院感染中图分类号:R725.5文献标志码:A文章编号:1003-515X(2007)
3、22-1707-02ClinicalAnalysisofNosocomialInfectionin71ChildrenwithAcuteLeukemiaJIAYue-ping,LIUGui-lan,ZHANGLe-ping,LUAi-dong(DepartmentofPediatrics,People′sHospitalofPekingUniversity,Beijing100044,China)Abstract:ObjectiveToexploretheclinicalcharacteristicsofnosocomialinfectioninchild
4、renwithacuteleukemiaandthestrategyofpre2ventionandtreatment.MethodsOnehundredandthirty-threecasesofnosocomialinfectioninchildrenwithacuteleukemiawereanalyzedbyretrospectivestudy.Therelationshipbetweennosocomialinfectionandstageofleukemia,hospitalizationduration,andtherateofinfecti
5、onwerein2vestigated.ResultsNosocomialinfectionratewas53.4%(71/133cases),significantdifferenceofinfectionratebetweenacutelymphoblasticleukemiaandnonlymphoblasticleukemiagroupwasfound(P<0.05).Thenosocomialinfectioncasesofthefirst3hospitalizationsgroupweremorethanthoseofothergroups(P
6、a<0.05),andthenosocomialinfectioncasesofhospitaliziondurationwithin7daysgroupweremorethanthoseofothergroups(Pa<0.05).Therewasnosignificantdifferenceinnumberofnosocomialinfectioncaseperpatientbetweenrelapseandnonrelapsegroups(P>0.05).Themainpathogensofsepticaemiaweregramnegativebac
7、illi,andtheyweregenerallysensitivetoAmicacinandPi2peracillin/tazobactam.ConclusionsChildrenwithacuteleukemiahavehighnosocomialinfectionrate.Theoccurrenceofnosocomialinfectionwasrelatedtothetypeandstageofleukemiaandhospitalizationdurationbutnottotheprognosis.Themainpathogensofsepti
8、caemiaweregramnegativebacilli.JAp
